Targeting nanoparticles to malignant tissues for improved diagnosis and therapy is a
popular concept. However, after surveying the literature from the past 10 years, only …

Excessive abnormal angiogenesis plays a pivotal role in tumor progression and is a
hallmark of solid tumors. This process is driven by an imbalance between pro-and anti …

Despite having an abundant number of vessels, tumours are usually hypoxic and nutrient-
deprived because their vessels malfunction. Such abnormal milieu can fuel disease …

Similarities between tumors and the inflammatory response associated with wound healing
have been recognized for more than 150 years and continue to intrigue. Some years ago …

It has become evident that we cannot understand tumour growth without considering
components of the stromal microenvironment, such as the vasculature. At the same time, the …

A recent explosion in newly discovered vascular growth factors has coincided with
exploitation of powerful new genetic approaches for studying vascular development. An …

Vascular endothelial growth factor (VEGF) is a homodimeric glycoprotein with a molecular
weight of approximately 45 kDa. It is the key mediator of angiogenesis (the formation of new …

Vascular endothelial growth factor A (VEGF-A), the founding member of the vascular
permeability factor (VPF)/VEGF family of proteins, is an important angiogenic cytokine with …

The extracellular matrix (ECM) is critical for all aspects of vascular biology. In concert with
supporting cells, endothelial cells (ECs) assemble a laminin-rich basement membrane …

1. From avascular to vascular It is clear that for vasculogenesis and angiogenesis to
effectively proceed during physiological and pathological From the earliest stages, the …