Multicomponent Click Reaction: An Indispensable Tool for Easy Access of Functionalized 1, 2, 3‐Triazoles

MS Yadav, S Rajkhowa, SK Singh, MK Jaiswal… - …, 2024 - Wiley Online Library
Multicomponent reactions are operationally simple and display a significant role in diverse
chemical modification by reducing reaction times as well as additional steps involved. In this …

Investigation of Huisgen's Noble metal catalyst click reaction mechanism for the synthesis of 1, 4-disubstituted 1, 2, 3-triazoles

AA Khairbek, MI Al-Zaben, R Puchta, MAAH Badawi… - Molecular …, 2024 - Elsevier
The current study delves into the mechanistic intricacies of azide-alkyne cycloaddition
reactions (MAAC) catalyzed by transition metals (M= Cu, Ag, and Au) bound to N …

Assessing the catalytic potential of novel halogen substituted carbene NHC (F, Cl, Br, I) catalysts in [3+ 2] cycloaddition reactions: A computational investigation

AA Khairbek, MAAH Badawi, AY Alzahrani… - Dalton …, 2024 - pubs.rsc.org
This study investigated the catalytic behavior of NHC-X ligands (X= F, Cl, Br, I) in
cycloaddition reactions, focusing on both mononuclear and binuclear pathways. Using NCI …

Silver-and gold-catalyzed azide− alkyne cycloaddition by functionalized NHC-based polynuclear catalysts: Computational investigation and mechanistic insights

AA Khairbek, MAAH Badawi, AYA Alzahrani… - Molecular …, 2025 - Elsevier
This study evaluated the catalytic efficiency of Au (I), Ag (I), and Cu (I) complexes in the
azide‒alkyne cycloaddition (AAC) reaction through density functional theory (DFT) …

Synthesis and spectroscopic studies of triazole-based macroheterocycles containing eudesmane-type sesquiterpenoid moieties

SS Patrushev, DO Vasil'eva, VI Krasnov… - Journal of Molecular …, 2025 - Elsevier
Chiral recognition is one of the most important and fascinating areas in supramolecular
chemistry. Chiral macrocycles, especially chiral macrocyclic hosts, having stable structures …

Click Chemistry and Bioorthogonal Chemistry: General Consideration from Discovery to Applications

VK Tiwari, MK Jaiswal, S Rajkhowa, SK Singh - Click Chemistry, 2024 - Springer
Click chemistry and bioorthogonal chemistry have significantly advanced the field of
chemical biology by enabling the precise and selective modification of biomolecules in …

Intramolecular Click Chemistry in Organic Synthesis

VK Tiwari, MK Jaiswal, S Rajkhowa, SK Singh - Click Chemistry, 2024 - Springer
Intramolecular click chemistry has become a valuable technique in the synthesis of complex
molecular architectures due to its high efficiency, selectivity, and ability to proceed under …

CuAAC 'Click Chemistry'-Mediated Synthesis of 1, 4-Disubstituted 1, 2, 3-Triazoles

VK Tiwari, MK Jaiswal, S Rajkhowa, SK Singh - Click Chemistry, 2024 - Springer
The Cu (I)-catalyzed azide-alkyne cycloaddition (CuAAC), a model click chemistry reaction
pivotal in synthesizing diverse 1, 4-disubstituted 1, 2, 3-triazoles with great ease. This …

Synthesis of Some New Chiral Triazole-oxazoline Derivatives

HR Dong - Current Organic Synthesis, 2025 - benthamdirect.com
Some new (S)-2-[1-aryl-5-methyl-1 H-1, 2, 3-triazol-4-yl]-4-benzyl-4, 5-dihydro-oxazoline
were synthesized by the reaction of (S)-N-(1-hydroxy-3-phenylpropan-2-yl)-1-aryl-5-methyl …

Thematic Issue: Emerging Aspects of Click Chemistry

VK Tiwari, D Sarma - Current Organic Synthesis, 2024 - ingentaconnect.com
The term “Click Chemistry”, first coined by KB Sharpless of the Scripps Research Institute in
2001, addresses a particular type of reactions that afford products in high yields with …