Insights into Alzheimer's disease from single-cell genomic approaches
Alzheimer's disease (AD) is an age-related disease pathologically defined by the deposition
of amyloid plaques and neurofibrillary tangles in the brain parenchyma. Single-cell profiling …
of amyloid plaques and neurofibrillary tangles in the brain parenchyma. Single-cell profiling …
Genetic regulation of RIPK1 and necroptosis
The receptor-interacting protein kinase 1 (RIPK1) is recognized as a master upstream
regulator that controls cell survival and inflammatory signaling as well as multiple cell death …
regulator that controls cell survival and inflammatory signaling as well as multiple cell death …
SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation
Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), is the ongoing global pandemic that poses …
syndrome coronavirus 2 (SARS-CoV-2), is the ongoing global pandemic that poses …
[HTML][HTML] Mitochondrial oxidative stress in brain microvascular endothelial cells: Triggering blood-brain barrier disruption
Y Wang, J Wu, J Wang, L He, H Lai, T Zhang, X Wang… - Mitochondrion, 2023 - Elsevier
Blood-brain barrier disruption plays an important role in central nervous system diseases.
This review provides information on the role of mitochondrial oxidative stress in brain …
This review provides information on the role of mitochondrial oxidative stress in brain …
Molecular and functional characteristics of receptor-interacting protein kinase 1 (RIPK1) and its therapeutic potential in Alzheimer's disease
Inflammation and cell death processes positively control the organ homeostasis of an
organism. Receptor-interacting protein kinase 1 (RIPK1), a member of the RIPK family, is a …
organism. Receptor-interacting protein kinase 1 (RIPK1), a member of the RIPK family, is a …
Spermidine mediates acetylhypusination of RIPK1 to suppress diabetes onset and progression
T Zhang, W Fu, H Zhang, J Li, B **ng, Y Cai… - Nature Cell …, 2024 - nature.com
It has been established that N-acetyltransferase (murine NAT1 (mNAT1) and human NAT2
(hNAT2)) mediates insulin sensitivity in type 2 diabetes. Here we show that mNAT1 …
(hNAT2)) mediates insulin sensitivity in type 2 diabetes. Here we show that mNAT1 …
Novel insights into RIPK1 as a promising target for future Alzheimer's disease treatment
S Li, L Qu, X Wang, L Kong - Pharmacology & Therapeutics, 2022 - Elsevier
Alzheimer's disease (AD) is an intractable neurodegenerative disease showing a clinical
manifestation with memory loss, cognitive impairment and behavioral dysfunction. The …
manifestation with memory loss, cognitive impairment and behavioral dysfunction. The …
NEK1-mediated retromer trafficking promotes blood–brain barrier integrity by regulating glucose metabolism and RIPK1 activation
Loss-of-function mutations in NEK1 gene, which encodes a serine/threonine kinase, are
involved in human developmental disorders and ALS. Here we show that NEK1 regulates …
involved in human developmental disorders and ALS. Here we show that NEK1 regulates …
RIPK1 activation in Mecp2-deficient microglia promotes inflammation and glutamate release in RTT
Z Cao, X Min, X **e, M Huang, Y Liu… - Proceedings of the …, 2024 - National Acad Sciences
Rett syndrome (RTT) is a devastating neurodevelopmental disorder primarily caused by
mutations in the methyl-CpG binding protein 2 (Mecp2) gene. Here, we found that inhibition …
mutations in the methyl-CpG binding protein 2 (Mecp2) gene. Here, we found that inhibition …
Necroptosis and Alzheimer's disease: pathogenic mechanisms and therapeutic opportunities
R Zhang, Y Song, X Su - Journal of Alzheimer's Disease, 2023 - content.iospress.com
Alzheimer's disease (AD) is considered to be the most common neurodegenerative disease,
with clinical symptoms encompassing progressive memory loss and cognitive impairment …
with clinical symptoms encompassing progressive memory loss and cognitive impairment …