Piperidines are among the most important synthetic fragments for designing drugs and play
a significant role in the pharmaceutical industry. Their derivatives are present in more than …

Because of the problems associated with opioids, drug discovery efforts have been
employed to develop opioids with reduced side effects using approaches such as biased …

Since the first discovery of antipsychotics in the 1950s, targeting dopaminergic drugs has
manifested to well manage the positive symptoms of schizophrenia with limited efficacy for …

Developmental and epileptic encephalopathies (DEEs) are complex conditions
characterized primarily by seizures associated with neurodevelopmental and motor deficits …

Drug development efforts that focused on single targets failed to provide effective treatment
for Alzheimer's disease (AD). Therefore, we designed cholinesterase inhibition (ChEI) …

Objective To evaluate whether fenfluramine (FFA) is associated with improvement in
everyday executive function (EF)—self-regulation—in preschool-aged children with Dravet …

Depression is the most common type of neuropsychiatric illness and has increasingly
become a major cause of disability. Unfortunately, the recent global pandemic of COVID-19 …

For the past several years, fundamental research on Sigma-1R (S1R) protein has unveiled
its necessity for maintaining proper cellular homeostasis through modulation of calcium and …

Background: Efferocytosis of apoptotic neurons by macrophages is essential for the
resolution of inflammation and for neuronal protection from secondary damage. It is known …

Introduction Pharmacotherapeutic options continue to expand for the treatment of chronic
non-cancer pain. There has been an increasing emphasis on multimodal analgesia. This …