Cellular senescence: defining a path forward
Cellular senescence is a cell state implicated in various physiological processes and a wide
spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence …
spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence …
Hallmarks of cellular senescence
A Hernandez-Segura, J Nehme, M Demaria - Trends in cell biology, 2018 - cell.com
Cellular senescence is a permanent state of cell cycle arrest that promotes tissue
remodeling during development and after injury, but can also contribute to the decline of the …
remodeling during development and after injury, but can also contribute to the decline of the …
Cellular senescence: aging, cancer, and injury
Cellular senescence is a permanent state of cell cycle arrest that occurs in proliferating cells
subjected to different stresses. Senescence is, therefore, a cellular defense mechanism that …
subjected to different stresses. Senescence is, therefore, a cellular defense mechanism that …
Cellular senescence: from physiology to pathology
D Muñoz-Espín, M Serrano - Nature reviews Molecular cell biology, 2014 - nature.com
Recent discoveries are redefining our view of cellular senescence as a trigger of tissue
remodelling that acts during normal embryonic development and upon tissue damage. To …
remodelling that acts during normal embryonic development and upon tissue damage. To …
A guide to assessing cellular senescence in vitro and in vivo
Cellular senescence is a physiological mechanism whereby a proliferating cell undergoes a
stable cell cycle arrest upon damage or stress and elicits a secretory phenotype. This highly …
stable cell cycle arrest upon damage or stress and elicits a secretory phenotype. This highly …
Mechanisms and functions of cellular senescence
N Herranz, J Gil - The Journal of clinical investigation, 2018 - Am Soc Clin Investig
Cellular senescence is a highly stable cell cycle arrest that is elicited in response to different
stresses. By imposing a growth arrest, senescence limits the replication of old or damaged …
stresses. By imposing a growth arrest, senescence limits the replication of old or damaged …
Mechanisms and regulation of cellular senescence
L Roger, F Tomas, V Gire - International journal of molecular sciences, 2021 - mdpi.com
Cellular senescence entails a state of an essentially irreversible proliferative arrest in which
cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic …
cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic …
Skin aging, cellular senescence and natural polyphenols
E Csekes, L Račková - International journal of molecular sciences, 2021 - mdpi.com
The skin, being the barrier organ of the body, is constitutively exposed to various stimuli
impacting its morphology and function. Senescent cells have been found to accumulate with …
impacting its morphology and function. Senescent cells have been found to accumulate with …
Cellular senescence at the crossroads of inflammation and Alzheimer's disease
A Guerrero, B De Strooper… - Trends in …, 2021 - cell.com
Aging is a key risk factor for Alzheimer's disease (AD), but the reasons for this association
are not well understood. Senescent cells accumulate in aged tissues and have been shown …
are not well understood. Senescent cells accumulate in aged tissues and have been shown …
Spatial map** of cellular senescence: emerging challenges and opportunities
AU Gurkar, AA Gerencser, AL Mora, AC Nelson… - Nature aging, 2023 - nature.com
Cellular senescence is a well-established driver of aging and age-related diseases. There
are many challenges to map** senescent cells in tissues such as the absence of specific …
are many challenges to map** senescent cells in tissues such as the absence of specific …