Revisiting the grammar of Tau aggregation and pathology formation: how new insights from brain pathology are sha** how we study and target Tauopathies
Converging evidence continues to point towards Tau aggregation and pathology formation
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …
The role of biomolecular condensates in protein aggregation
There is an increasing amount of evidence that biomolecular condensates are linked to
neurodegenerative diseases associated with protein aggregation, such as Alzheimer's …
neurodegenerative diseases associated with protein aggregation, such as Alzheimer's …
Tau liquid–liquid phase separation in neurodegenerative diseases
Aggregation of the microtubule-associated protein tau plays a major role in Alzheimer's
disease and several other neurodegenerative disorders. An exciting recent development is …
disease and several other neurodegenerative disorders. An exciting recent development is …
Conformational expansion of tau in condensates promotes irreversible aggregation
Liquid–liquid phase separation (LLPS) of proteins into biomolecular condensates has
emerged as a fundamental principle underpinning cellular function and malfunction. Indeed …
emerged as a fundamental principle underpinning cellular function and malfunction. Indeed …
Mammalian telomeric RNA (TERRA) can be translated to produce valine–arginine and glycine–leucine dipeptide repeat proteins
TM Al-Turki, JD Griffith - Proceedings of the National …, 2023 - National Acad Sciences
Mammalian telomeres consist of (TTAGGG) n repeats. Transcription of the C-rich strand
generates a G-rich RNA, termed TERRA, containing G-quadruplex structures. Recent …
generates a G-rich RNA, termed TERRA, containing G-quadruplex structures. Recent …
Protein interaction networks in neurodegenerative diseases: From physiological function to aggregation
The accumulation of protein inclusions is linked to many neurodegenerative diseases that
typically develop in older individuals, due to a combination of genetic and environmental …
typically develop in older individuals, due to a combination of genetic and environmental …
Heterotypic electrostatic interactions control complex phase separation of tau and prion into multiphasic condensates and co-aggregates
SK Rai, R Khanna, A Avni… - Proceedings of the …, 2023 - National Acad Sciences
Biomolecular condensates formed via phase separation of proteins and nucleic acids are
thought to perform a wide range of critical cellular functions by maintaining spatiotemporal …
thought to perform a wide range of critical cellular functions by maintaining spatiotemporal …
Emerging roles of O-glycosylation in regulating protein aggregation, phase separation, and functions
Protein O-glycosylation is widely identified in various proteins involved in diverse biological
processes. Recent studies have demonstrated that O-glycosylation plays crucial and …
processes. Recent studies have demonstrated that O-glycosylation plays crucial and …
Liquid–liquid phase separation of tau: From molecular biophysics to physiology and disease
Biomolecular condensation via liquid–liquid phase separation (LLPS) of intrinsically
disordered proteins/regions (IDPs/IDRs), with and without nucleic acids, has drawn …
disordered proteins/regions (IDPs/IDRs), with and without nucleic acids, has drawn …
Molecular crowding and RNA synergize to promote phase separation, microtubule interaction, and seeding of Tau condensates
J Hochmair, C Exner, M Franck… - The EMBO …, 2022 - embopress.org
Biomolecular condensation of the neuronal microtubule‐associated protein Tau (MAPT) can
be induced by coacervation with polyanions like RNA, or by molecular crowding. Tau …
be induced by coacervation with polyanions like RNA, or by molecular crowding. Tau …