Due to improved phenoty** and genetic characterization, the field of 'incurable'and
'blinding'inherited retinal diseases (IRDs) has moved substantially forward. Decades of …

Inherited retinal dystrophies (IRDs) are a group of clinically and genetically heterogeneous
degenerative disorders. To date, mutations have been associated with IRDs in over 270 …

MERTK is an essential component of the signaling network that controls phagocytosis in
retinal pigment epithelium (RPE), the loss of which results in photoreceptor degeneration …

Leber congenital amaurosis (LCA) is a severe congenital/early-onset retinal dystrophy.
Given its monogenic nature and the immunological and anatomical privileges of the eye …

Retinitis pigmentosa (RP) poses a significant threat to eye health worldwide, with
prevalence rates of 1 in 5000 worldwide. This genetically diverse retinopathy is …

MER tyrosine kinase (MERTK) encodes a surface receptor localized at the apical membrane
of the retinal pigment epithelium. It plays a critical role in photoreceptor outer segment …

Vascular endothelial growth factor A (VEGFA) is involved in the pathogenesis of
vasoproliferative retinal diseases, such as exudative age-related macular degeneration …

While individually classed as rare diseases, hereditary retinal degenerations (IRDs) are the
major cause of registered visual handicap in the developed world. Given their hereditary …

Purpose: Prospective treatments for age-related macular degeneration and inherited retinal
degenerations are commonly evaluated in the Royal College of Surgeons (RCS) rat before …

As our understanding of the genetic basis for inherited retinal disease has expanded, gene
therapy has advanced into clinical development. When the gene mutations associated with …