During almost 40 years of use, the micronucleus assay (MN) has become one of the most
popular methods to assess genotoxicity of different chemical and physical factors, including …

Introduction Genomic instability, a major driving force of cancer and agerelated diseases,
poses an ominous threat to human health and longevity. Nevertheless, several stringent and …

Genome editing has therapeutic potential for treating genetic diseases and cancer.
However, the currently most practicable approaches rely on the generation of DNA double …

Currently, we need emerging initial data regarding how plastic exposures affect cellular and
molecular components and how such interactions will be crucial for human health. We …

The EFSA Scientific Committee was asked to provide guidance on the most appropriate in
vivo tests to follow up on positive in vitro results for aneugenicity, and on the approach to risk …

Exosome cargoes are highly varied and include proteins, small RNAs, and genomic DNA
(gDNA). The presence of gDNA suggests that different intracellular compartments contribute …

Abstract The Biomarkers of Nutrition for Development (BOND) project is designed to provide
evidence-based advice to anyone with an interest in the role of nutrition in health …

Microplastics (MPs) are critical emerging pollutants found in the environment worldwide;
however, its toxicity in aquatic in amphibians, is poorly known. Thus, the aim of the present …

During mitotic exit, missegregated chromosomes can recruit their own nuclear envelope
(NE) to form micronuclei (MN). MN have reduced functioning compared to primary nuclei in …

During apoptosis, the mitochondrial outer membrane is permeabilized, leading to the
release of cytochrome c that activates downstream caspases. Mitochondrial outer …