The SWI/SNF complex is an evolutionarily conserved multi-subunit chromatin-remodelling
complex, which uses the energy of ATP hydrolysis to mobilize nucleosomes and remodel …

Merkel cell carcinoma (MCC) is an aggressive neuroendocrine carcinoma of the skin with
two distinct etiologies. Clonal integration of Merkel cell polyomavirus DNA into the tumor …

Gastric cancer (GC), one of the most common malignant tumors in the world, exhibits a rapid
metastasis rate and causes high mortality. Diagnostic markers and potential therapeutic …

The NuA4 histone acetyltransferase (HAT) multisubunit complex is responsible for
acetylation of histone H4 and H2A N-terminal tails in yeast. Its catalytic component, Esa1, is …

Coactivator-associated arginine methyltransferase 1 (CARM1), a coactivator for various
cancer-relevant transcription factors, is overexpressed in breast cancer. To elucidate the …

A paradox for the cancer biology field has been the revelation that oncogenes, once thought
to simply provide advantages to a cancer cell, actually put it at dire risk of cell suicide. Myc is …

Histone acetyltransferase complexes have been shown to be key regulators of gene
expression. Among these, the NuA4 complex, first characterized in yeast, stands out as it …

The transcription factor MYC binds specific DNA sites in cellular chromatin and induces the
acetylation of histones H3 and H4. However, the histone acetyltransferases (HATs) that are …

The histone acetyltransferases (HATs) of the MYST family are highly conserved in
eukaryotes and carry out a significant proportion of all nuclear acetylation. These enzymes …

Tandem affinity purification (TAP) is a generic two-step affinity purification protocol that
enables the isolation of protein complexes under close-to-physiological conditions for …