It is apparent that various functional units within the cellular machinery are derived from
RNAs. The evolution of sequencing techniques has resulted in significant insights into …

Adaptive immunity provides protection against infectious and malignant diseases. These
effects are mediated by lymphocytes that sense and respond with targeted precision to …

The memory CD8+ T cell pool contains phenotypically and transcriptionally heterogeneous
subsets with specialized functions and recirculation patterns. Here, we examined the …

Regulatory T (Treg) cells play a critical regulatory role in the immune system by suppressing
excessive immune responses and maintaining immune balance. The effective migration of …

Lamina-associated domains (LADs) are large chromatin regions that are associated with the
nuclear lamina (NL) and form a repressive environment for transcription. The molecular …

Clostridioides difficile (C. difficile) is a global threat and has significant implications for
individuals and health care systems. Little is known about host molecular mechanisms and …

ARID1A deletion mutation contributes to improved treatment of several malignancies with
immune checkpoint inhibitors (ICIs). However, its role in modulating of tumor immune …

SWI/SNF enzymes are heterogeneous multi-subunit complexes that utilize the energy from
ATP hydrolysis to remodel chromatin structure, facilitating transcription, DNA replication, and …

Clinical trials have identified ARID1A mutations as enriched among patients who respond
favorably to immune checkpoint blockade (ICB) in several solid tumor types independent of …

Coordination of transcription factors and SWI–SNF complexes regulates chromatin priming in
develo** T cells | Nature Immunology Skip to main content Thank you for visiting nature.com …