Turnitin
降AI改写
早检测系统
早降重系统
Turnitin-UK版
万方检测-期刊版
维普编辑部版
Grammarly检测
Paperpass检测
checkpass检测
PaperYY检测
New insights into butyrylcholinesterase: Pharmaceutical applications, selective inhibitors and multitarget-directed ligands
T Sun, T Zhen, CH Harakandi, L Wang, H Guo… - European Journal of …, 2024 - Elsevier
Butyrylcholinesterase (BChE), also known as pseudocholinesterase and serum
cholinesterase, is an isoenzyme of acetylcholinesterase (AChE). It mediates the degradation …
cholinesterase, is an isoenzyme of acetylcholinesterase (AChE). It mediates the degradation …
Sulfonamide Derivatives: Recent Compounds with Potent Anti-alzheimer's Disease Activity
MC Egbujor - Central Nervous System Agents in Medicinal …, 2024 - benthamdirect.com
Facile synthetic procedures and broad spectrum of biological activities are special attributes
of sulfonamides. Sulfonamide derivatives have demonstrated potential as a class of …
of sulfonamides. Sulfonamide derivatives have demonstrated potential as a class of …
Exploring the potential of sulfonamide-dihydropyridine hybrids as multitargeted ligands for Alzheimer's disease treatment
I Dakhlaoui, PJ Bernard, D Pietrzak, A Simakov… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is a multifactorial neurodegenerative disease that has a heavy
social and economic impact on all societies and for which there is still no cure. Multitarget …
social and economic impact on all societies and for which there is still no cure. Multitarget …
Identification of potential death-associated protein kinase-1 (DAPK1) inhibitors by an integrated ligand-based and structure-based computational drug design …
Death-associated protein kinase 1 (DAPK1) is a calcium/calmodulin (Ca2+/CaM)-dependent
serine/threonine kinase that is abundantly expressed in the memory-and cognition-related …
serine/threonine kinase that is abundantly expressed in the memory-and cognition-related …
Development of multi-targetable chalcone derivatives bearing N-aryl piperazine moiety for the treatment of Alzheimer's disease
The multi-target directed ligand (MTDL) discovery has been gaining immense attention in
the development of therapeutics for Alzheimer's disease (AD). The strategy has been …
the development of therapeutics for Alzheimer's disease (AD). The strategy has been …
Identification of novel glucocerebrosidase chaperone for potential treatment of Parkinson's disease: An approach using in silico virtual screening, molecular docking …
Abstract Glucocerebrosidase (GCase), a GBA1 gene-encoded lysosomal enzyme, is a risk
factor for Parkinson's disease (PD). Chaperones that increase GCase activity can potentially …
factor for Parkinson's disease (PD). Chaperones that increase GCase activity can potentially …
Design, synthesis, molecular docking and pharmacological evaluation of some thiadiazole based nipecotic acid derivatives as a potential anticonvulsant and …
In our continuous effort to develop novel antiepileptic drug, a new series of nipecotic acid
derivatives having1, 3, 4-thiadiazole nucleus were designed and synthesized. This study …
derivatives having1, 3, 4-thiadiazole nucleus were designed and synthesized. This study …
Discovery of pyrazoline analogs as multi-targeting cholinesterase, β-secretase and Aβ aggregation inhibitors through lead optimization strategy
The multi-target directed ligands (MTDLs) strategy has been evolved as the propitious
approach for the development of therapeutics for Alzheimer's disease (AD). In an earlier …
approach for the development of therapeutics for Alzheimer's disease (AD). In an earlier …
Carltonine-derived compounds for targeted butyrylcholinesterase inhibition
F Pidany, J Kroustkova, J Jenco… - RSC Medicinal …, 2024 - pubs.rsc.org
The investigation into human butyrylcholinesterase (hBChE) inhibitors as therapeutic agents
for Alzheimer's disease (AD) holds significant promise, addressing both symptomatic relief …
for Alzheimer's disease (AD) holds significant promise, addressing both symptomatic relief …
Effect of sulfonamide derivatives of phenylglycine on scopolamine‐induced amnesia in rats
Alzheimer's disease is a neurodegenerative disease responsible for dementia and other
neuropsychiatric symptoms. In the present study, compounds 30 and 33, developed earlier …
neuropsychiatric symptoms. In the present study, compounds 30 and 33, developed earlier …