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[HTML][HTML] Peptidomic analysis of urine from youths with early type 1 diabetes reveals novel bioactivity of uromodulin peptides in vitro
JAD Van, S Clotet-Freixas, J Zhou, I Batruch… - Molecular & Cellular …, 2020 - Elsevier
Chronic hyperglycemia is known to disrupt the proteolytic milieu, initiating compensatory
and maladaptive pathways in the diabetic kidney. Such changes in intrarenal proteolysis are …
and maladaptive pathways in the diabetic kidney. Such changes in intrarenal proteolysis are …
Meprin β metalloproteases associated with differential metabolite profiles in the plasma and urine of mice with type 1 diabetes and diabetic nephropathy
J Gooding, L Cao, C Whitaker, JM Mwiza, M Fernander… - BMC nephrology, 2019 - Springer
Background Meprin metalloproteases are abundantly expressed in the brush border
membranes of kidney proximal tubules and small intestines. Meprins are also expressed in …
membranes of kidney proximal tubules and small intestines. Meprins are also expressed in …
Inflammation and kidney injury in diabetic African American men
L Cao, A Boston, O Jegede… - Journal of Diabetes …, 2019 - Wiley Online Library
African Americans are disproportionately burdened by diabetic kidney disease (DKD).
However, little is known about the cellular and molecular mechanisms underlying the onset …
However, little is known about the cellular and molecular mechanisms underlying the onset …
LC-MS-based metabolomics analysis to identify meprin-β-associated changes in kidney tissue from mice with STZ-induced type 1 diabetes and diabetic kidney injury
J Gooding, L Cao, F Ahmed… - American Journal …, 2019 - journals.physiology.org
Meprin metalloproteases have been implicated in the pathophysiology of diabetic kidney
disease (DKD). Single-nucleotide polymorphisms in the meprin-β gene have been …
disease (DKD). Single-nucleotide polymorphisms in the meprin-β gene have been …
[KNJIGA][B] Analyses of the Urinary Peptidome and Proteome of Early Type 1 Diabetes
JAD Van - 2020 - search.proquest.com
Diabetic kidney disease is the leading cause of end-stage renal disease worldwide. The
early mechanisms responsible for the initiation and progression of diabetic kidney disease …
early mechanisms responsible for the initiation and progression of diabetic kidney disease …
[PDF][PDF] Peptidomic analysis of urine from youths with early type 1 diabetes reveals novel bioactivity
JAD Van, S Clotet-Freixas, J Zhou, I Batruch, C Sun - Diabetes Care - researchgate.net
Chronic hyperglycemia is known to disrupt the proteolytic milieu, initiating compensatory
and maladaptive pathways in the diabetic kidney. Such changes in intrarenal proteolysis are …
and maladaptive pathways in the diabetic kidney. Such changes in intrarenal proteolysis are …