Antibiotic resistance is a global health emergency, with resistance detected to all antibiotics
currently in clinical use and only a few novel drugs in the pipeline. Understanding the …

Throughout their evolutionary history, bacteria have faced diverse threats from other
microorganisms, including competing bacteria, bacteriophages and predators. In response …

Microbial resistance to classical antibiotics and its rapid progression have raised serious
concern in the treatment of infectious diseases. Recently, many studies have been directed …

Background Helicobacter pylori is one of the most prevalent global pathogens and can lead
to gastrointestinal disease including peptic ulcers, gastric marginal zone lymphoma and …

Most of the antibacterial activities of essential oils from the Lamiaceae herbaceous plant
family thyme and oregano are attributed to their bioactive isomeric monoterpenoid …

Discovery of antibiotics acting against Gram-negative species is uniquely challenging due to
their restrictive penetration barrier. BamA, which inserts proteins into the outer membrane, is …

Excessive use of antibiotics has led to the emergence of multidrug-resistant bacteria that are
a serious threat to human health. There is a need to develop efficient antibacterial agents to …

The presence of antibiotics can exert significant selection pressure on the emergence and
spread of antibiotic resistance genes (ARGs) and antibiotic resistant bacteria (ARB) …

Efflux pumps are widely implicated in antibiotic resistance because they can extrude the
majority of clinically relevant antibiotics from within cells to the extracellular environment …

Background Bacterial biofilms are aggregation or collection of different bacterial cells which
are covered by self-produced extracellular matrix and are attached to a substratum …