Dendritic and axonal morphology reflects the input and output of neurons and is a defining
feature of neuronal types,, yet our knowledge of its diversity remains limited. Here, to …

An essential step toward understanding brain function is to establish a structural framework
with cellular resolution on which multi-scale datasets spanning molecules, cells, circuits and …

One intrinsic yet critical issue that troubles the field of fluorescence microscopy ever since its
introduction is the unmatched resolution in the lateral and axial directions (ie, resolution …

We developed a dual-adeno-associated-virus expression system that enables strong and
sparse labeling of individual neurons with cell-type and projection specificity. We …

A paradigm shift is occurring in neuroscience and in general in life sciences converting
biomedical research from a descriptive discipline into a quantitative, predictive, actionable …

A thorough neuroanatomical study of the brain architecture is crucial for understanding its
cellular compositions, connections, and working mechanisms. However, the fine-and …

Through synaptic connections, long-range circuits transmit information among neurons and
connect different brain regions to form functional motifs and execute specific functions …

Brain circuits comprise vast numbers of interconnected neurons with diverse molecular,
anatomical and physiological properties. To allow targeting of individual neurons for …

Parsing diverse nerve cells into biological types is necessary for understanding neural
circuit organization. Morphology is an intuitive criterion for neuronal classification and a …

The secondary motor cortex (MOs) plays crucial roles in cognitive and executive processes
and has reciprocal connections with numerous cortices in rodents. However, descriptions of …