The prompt removal of apoptotic cells by phagocytes is important for maintaining tissue
homeostasis. The molecular and cellular events that underpin apoptotic cell recognition and …

Higher organisms rely on a closed cardiovascular circulatory system with blood vessels
supplying vital nutrients and oxygen to distant tissues. Not surprisingly, vascular pathologies …

Proper coordination of cholesterol biosynthesis and trafficking is essential to human health.
The sterol regulatory element–binding proteins (SREBPs) are key transcription regulators of …

Plasma HDL levels have a protective role in atherosclerosis, yet clinical therapies to raise
HDL levels have remained elusive. Recent advances in the understanding of lipid …

Reverse cholesterol transport (RCT) is a term used to describe the efflux of excess cellular
cholesterol from peripheral tissues and its return to the liver for excretion in the bile and …

HDL metabolism represents a major target for the development of therapies intended to
reduce the risk of atherosclerotic cardiovascular disease. HDL metabolism is complex and …

Macrophage ATP-binding cassette transporter A1 (ABCA1), scavenger receptor class B type
I (SR-BI), and ABCG1 have been shown to promote cholesterol efflux to extracellular …

Atherosclerosis, the pathological basis of most cardiovascular disease (CVD), is closely
associated with cholesterol accumulation in the arterial intima. Excessive cholesterol is …

Rationale: High-density lipoprotein (HDL) is a heterogeneous population of particles.
Differences in the capacities of HDL subfractions to remove cellular cholesterol may explain …

Background and Purpose The gut microbial metabolite butyrate is linked to the modulation
of metabolic disease. The mechanism by which butyrate effects in atherosclerosis is …