Peroxisomes are subcellular organelles that play a central role in human physiology by
catalyzing a range of unique metabolic functions. The importance of peroxisomes for human …

The endoplasmic reticulum is an important intracellular organelle that plays an important
role in maintaining cellular homeostasis. Endoplasmic reticulum stress (ERS) and unfolded …

Ferroptosis is a type of iron-dependent regulated cell death, representing an emerging
disease-modulatory mechanism. Transcription factors play multiple roles in ferroptosis …

Autophagy is activated by prolonged fasting but cannot overcome the ensuing hepatic lipid
overload, resulting in fatty liver. Here, we describe a peroxisome-lysosome metabolic link …

Metabolic reprogramming is a hallmark of cancer. However, it is not well known how
metabolism affects cancer progression. We identified that metabolic enzyme acyl-CoA …

Peroxisomes account for~ 35% of total H2O2 generation in mammalian tissues. Peroxisomal
ACOX 1 (acyl‐CoA oxidase 1) is the first and rate‐limiting enzyme in fatty acid β‐oxidation …

The liver gene expression of the peroxisomal β-oxidation enzyme acyl-coenzyme A oxidase
1 (ACOX1), which catabolizes very long chain fatty acids (VLCFA), increases in the context …

Peroxisomes are key metabolic organelles, which contribute to cellular lipid metabolism, eg
the β-oxidation of fatty acids and the synthesis of myelin sheath lipids, as well as cellular …

The endoplasmic reticulum (ER) is commonly referred to as the factory of the cell, as it is
responsible for a large amount of protein and lipid synthesis. As a membrane-bound …

Background & Aims CD147 is a transmembrane glycoprotein which is highly expressed in
various human cancers including hepatocellular carcinoma (HCC). A drug Licartin …