Neurons are among the most compartmentalized and interactive of all cell types. Like all
cells, neurons use proteins as the main sensors and effectors. The modification of the …

The elaborate morphology of neurons together with the information processing that occurs in
remote dendritic and axonal compartments makes the use of decentralized cell biological …

Owing to their morphological complexity and dense network connections, neurons modify
their proteomes locally, using mRNAs and ribosomes present in the neuropil (tissue …

Vigorous transport of cytoplasmic components along axons over substantial distances is
crucial for the maintenance of neuron structure and function. The transport of mitochondria …

The complexity of the human brain poses a substantial challenge for the development of
models of the CNS. Current animal models lack many essential human characteristics (in …

Abstract mRNAs can be targeted to specific neuronal subcellular domains, which enables
rapid changes in the local proteome through local translation. This mRNA-based …

The assembly of a new growth cone is a prerequisite for axon regeneration after injury.
Creation of a new growth cone involves multiple processes, including calcium signalling …

Spatial restriction of mRNA to distinct subcellular locations enables local regulation and
synthesis of proteins. However, the organizing principles of mRNA localization remain …

The subcellular position of a protein is a key determinant of its function. Mounting evidence
indicates that RNA localization, where specific mRNAs are transported subcellularly and …

The importance of subcellular mRNA localization is well established, but the underlying
mechanisms mostly remain an enigma. Early studies suggested that specific mRNA …