Rho GTPases regulate cytoskeletal and cell adhesion dynamics and thereby coordinate a
wide range of cellular processes, including cell migration, cell polarity and cell cycle …

RAC1 signalling has been implicated in a variety of dynamic cell biological processes that
are orchestrated through regulated localisation and activation of RAC1. As a small GTPase …

Aberrant WNT signaling drives colorectal cancer (CRC). Here, we identify TIAM1 as a critical
antagonist of CRC progression through inhibiting TAZ and YAP, effectors of WNT signaling …

Summary The small Rho GTPase RAC1 is an essential regulator of cellular signaling that
controls actin rearrangements and cell motility. Here, we identify a novel CUL3 RING …

Background The tumor microenvironment has complex effects in cancer pathophysiology
that are not fully understood. Most cancer therapies are directed against malignant cells …

The E3 ubiquitin ligase HUWE1, deregulated in carcinoma, has been implicated in tumor
formation. Here, we uncover a role for HUWE1 in cell migration and invasion through …

The dentate gyrus (DG) controls information flow into the hippocampus and is critical for
learning, memory, pattern separation, and spatial coding, while DG dysfunction is …

Excitatory synapses and the actin-rich dendritic spines on which they reside are
indispensable for information processing and storage in the brain. In the adult hippocampus …

Glioblastoma (GBM) is regarded as the most common primary intracranial neoplasm.
Despite standard treatment with tumor resection and radiochemotherapy, the outcome …

The Tiam family proteins—Tiam1 and Tiam2/STEF—are Rac1-specific Guanine Nucleotide
Exchange Factors (GEFs) with important functions in epithelial, neuronal, immune and other …