The field of regenerative medicine provides enormous opportunities for generating beta
cells from different stem cell sources for cellular therapy. Even though insulin-secreting cells …

Type 1 diabetes (T1D) is the third most common autoimmune disease which develops due
to genetic and environmental risk factors. Often, intensive insulin therapy is insufficient, and …

An unlimited source of human pancreatic β cells is in high demand. Even with recent
advances in pancreatic differentiation from human pluripotent stem cells, major hurdles …

Diabetes is a metabolic disease which affects not only glucose metabolism but also lipid and
protein metabolism. It encompasses two major types: type 1 and 2 diabetes. Despite the …

Diabetes mellitus is a chronic disease that affects hundreds of millions of people worldwide.
Type 1 diabetes (T1D) is characterized by the lack of pancreatic β-cells that had been …

Background: Endogenous pancreatic β-cell regeneration is a promising therapeutic
approach for enhancing β-cell function and neogenesis in diabetes. Various findings have …

Abstract Ethnopharmacological relevance Zanthoxylum chalybeum Engl. is endemic to
Africa and has been used traditionally to treat diabetes mellitus. Moreover, its …

Background Transplantation of differentiated cells from human-induced pluripotent stem
cells (hiPSCs) holds great promise for clinical treatments. Eliminating the risk factor of …

Diabetes mellitus is characterized by chronic high blood glucose levels resulted from
deficiency and/or dysfunction of insulin-producing pancreatic β cells. Generation of large …

Objectives It has been shown that growth factors and small molecules play an essential role
in the proliferation of β cells and insulin production. In this study, we investigated the effects …