The microtubule-based spindle orchestrates chromosome segregation during cell division.
Following more than a century of study, many components and pathways contributing to …

The mitotic spindle is the macromolecular machine that segregates chromosomes to two
daughter cells during mitosis. The major structural elements of the spindle are microtubule …

Mitotic cells face the challenging tasks of linking kinetochores to growing and shortening
microtubules and actively regulating these dynamic attachments to produce accurate …

Merotelic kinetochore orientation is a misattachment in which a single kinetochore binds
microtubules from both spindle poles rather than just one and can produce anaphase …

Chromosome segregation during cell division requires a bipolar mitotic spindle. Therefore,
how the spindle is formed, maintained, and functions is of fundamental importance for all …

Accurate segregation of chromosomes during cell division is accomplished through the
assembly of a bipolar microtubule-based structure called the mitotic spindle. Work over the …

The mitotic spindle assembles to a steady-state length at metaphase through the integrated
action of molecular mechanisms that generate and respond to mechanical forces. While …

Mitotic spindle microtubules (MT s) undergo continuous poleward flux, whose driving force
and function in humans remain unclear. Here, we combined loss‐of‐function screenings …

During cell division, mitotic spindle microtubules segregate chromosomes by exerting forces
on kinetochores. What forces drive chromosome segregation in anaphase remains a central …

The microtubule (MT) cytoskeleton supports a broad range of cellular functions, from
providing tracks for intracellular transport, to supporting movement of cilia and flagella, to …