Importance The prevalence of irritable bowel syndrome (IBS) in the United States is between
7% and 16%, most common in women and young people, with annual direct costs estimated …

Irritable bowel syndrome (IBS) is one of the most common disorders of gut–brain interaction
worldwide, defined according to patterns of gastrointestinal symptoms as described by the …

Paediatric functional abdominal pain disorders, currently referred to as disorders of gut–
brain interaction, comprise irritable bowel syndrome, functional dyspepsia, abdominal …

Irritable bowel syndrome (IBS) is a common, symptom-based condition that has negative
effects on quality of life and costs health care systems billions of dollars each year. Until …

Objective To appraise the evidence that pathophysiological mechanisms and individualised
treatment directed at those mechanisms provide an alternative approach to the treatment of …

The pathophysiology of irritable bowel syndrome (IBS) is multifactorial and probably
involves genetic predisposition and the effect of environmental factors. Unlike other …

Background: Disorders of gut–brain interaction (DGBIs) have a complex pathophysiology
that is often characterized by a relationship between food ingestion and triggering of …

Dietary advice constitutes a treatment strategy for irritable bowel syndrome (IBS). We aimed
to examine the effect of a starch-and sucrose-reduced diet (SSRD) on gastrointestinal …

Recently in Gut and elsewhere, 1–3 rare and common hypomorphic sucrase-isomaltase (SI)
gene variants have been linked to an increased risk of IBS. Similar to congenital SI …

There has been a renewed interest in the role of dietary therapies to manage irritable bowel
syndrome (IBS), with diet high on the agenda for patients. Currently, interest has focussed …