New insights into nucleosome and chromatin structure: an ordered state or a disordered affair?
The compaction of genomic DNA into chromatin has profound implications for the regulation
of key processes such as transcription, replication and DNA repair. Nucleosomes, the …
of key processes such as transcription, replication and DNA repair. Nucleosomes, the …
DNA structure and function
A Travers, G Muskhelishvili - The FEBS journal, 2015 - Wiley Online Library
The proposal of a double‐helical structure for DNA over 60 years ago provided an eminently
satisfying explanation for the heritability of genetic information. But why is DNA, and not …
satisfying explanation for the heritability of genetic information. But why is DNA, and not …
[HTML][HTML] Chromatin fibers are formed by heterogeneous groups of nucleosomes in vivo
Nucleosomes help structure chromosomes by compacting DNA into fibers. To gain insight
into how nucleosomes are arranged in vivo, we combined quantitative super-resolution …
into how nucleosomes are arranged in vivo, we combined quantitative super-resolution …
Nucleosome plasticity is a critical element of chromatin liquid–liquid phase separation and multivalent nucleosome interactions
Liquid–liquid phase separation (LLPS) is an important mechanism that helps explain the
membraneless compartmentalization of the nucleus. Because chromatin compaction and …
membraneless compartmentalization of the nucleus. Because chromatin compaction and …
Histone H2B ubiquitylation disrupts local and higher-order chromatin compaction
Regulation of chromatin structure involves histone posttranslational modifications that can
modulate intrinsic properties of the chromatin fiber to change the chromatin state. We used …
modulate intrinsic properties of the chromatin fiber to change the chromatin state. We used …
Chromatin higher-order structure and dynamics
CL Woodcock, RP Ghosh - Cold Spring Harbor …, 2010 - cshperspectives.cshlp.org
The primary role of the nucleus as an information storage, retrieval, and replication site
requires the physical organization and compaction of meters of DNA. Although it has been …
requires the physical organization and compaction of meters of DNA. Although it has been …
Recent advances in magnetic tweezers
Since their first demonstration of manipulation and mechanical coiling of a single DNA
molecule, magnetic tweezers have become a popular and widely used single-molecule …
molecule, magnetic tweezers have become a popular and widely used single-molecule …
Columnar structure of human telomeric chromatin
Telomeres, the ends of eukaryotic chromosomes, play pivotal parts in ageing and cancer
and are targets of DNA damage and the DNA damage response,,,–. Little is known about the …
and are targets of DNA damage and the DNA damage response,,,–. Little is known about the …
Chromatin structure: does the 30-nm fibre exist in vivo?
K Maeshima, S Hihara, M Eltsov - Current opinion in cell biology, 2010 - Elsevier
A long strand of DNA is wrapped around the core histone and forms a nucleosome.
Although the nucleosome has long been assumed to be folded into 30-nm chromatin fibres …
Although the nucleosome has long been assumed to be folded into 30-nm chromatin fibres …
Uncovering the forces between nucleosomes using DNA origami
JJ Funke, P Ketterer, C Lieleg, S Schunter, P Korber… - Science …, 2016 - science.org
Revealing the energy landscape for nucleosome association may contribute to the
understanding of higher-order chromatin structures and their impact on genome regulation …
understanding of higher-order chromatin structures and their impact on genome regulation …