The cellular and physiological basis for lung repair and regeneration: past, present, and future

MC Basil, J Katzen, AE Engler, M Guo, MJ Herriges… - Cell stem cell, 2020‏ - cell.com
The respiratory system, which includes the trachea, airways, and distal alveoli, is a complex
multi-cellular organ that intimately links with the cardiovascular system to accomplish gas …

ECM and epithelial stem cells: the scaffold of destiny

S Estrach, CM Vivier, CC Féral - Frontiers in Cell and Developmental …, 2024‏ - frontiersin.org
Adult stem cells play a critical role in maintaining tissue homeostasis and promoting
longevity. The intricate organization and presence of common markers among adult …

Diversity of interstitial lung fibroblasts is regulated by platelet-derived growth factor receptor α kinase activity

J Green, M Endale, H Auer, AKT Perl - American journal of …, 2016‏ - atsjournals.org
Epithelial–mesenchymal cell interactions and factors that control normal lung development
are key players in lung injury, repair, and fibrosis. A number of studies have investigated the …

[HTML][HTML] VAPIng into ARDS: Acute respiratory distress syndrome and cardiopulmonary failure

MA Sussman - Pharmacology & therapeutics, 2022‏ - Elsevier
Abstract “Modern” va** involving battery-operated electronic devices began
approximately one dozen years and has quickly evolved into a multibillion dollar industry …

Adult lung stem cells and their contribution to lung tumourigenesis

ML Asselin-Labat, CE Filby - Open biology, 2012‏ - royalsocietypublishing.org
The isolation and characterization of lung stem and progenitor cells represent an important
step towards the understanding of lung repair after injury, lung disease pathogenesis and …

Concise review: Deconstructing the lung to reveal its regenerative potential

JL McQualter, I Bertoncello - Stem Cells, 2012‏ - academic.oup.com
Despite burgeoning interest in the potential of cellular therapies in lung regenerative
medicine, progress in delivering these therapies has been confounded by a lack of …

Amnion epithelial cells as a candidate therapy for acute and chronic lung injury

RJ Hodges, R Lim, G Jenkin… - Stem cells …, 2012‏ - Wiley Online Library
Acute and chronic lung injury represents a major and growing global burden of disease. For
many of these lung diseases, the damage is irreparable, exhausting the host's ability to …

Interrupted reprogramming of alveolar type II cells induces progenitor-like cells that ameliorate pulmonary fibrosis

L Guo, G Karoubi, P Duchesneau, FG Aoki… - NPJ Regenerative …, 2018‏ - nature.com
We describe here an interrupted reprogramming strategy to generate “induced progenitor-
like (iPL) cells” from alveolar epithelial type II (AEC-II) cells. A carefully defined period of …

Lung stem cells: do they exist?

I Bertoncello, JL McQualter - Respirology, 2013‏ - Wiley Online Library
Recognition of the potential of stem cell‐based therapies for alleviating intractable lung
diseases has provided the impetus for research aimed at identifying regenerative cells in the …

The promise of stem cells in bronchopulmonary dysplasia

M O'Reilly, B Thébaud - Seminars in Perinatology, 2013‏ - Elsevier
Bronchopulmonary dysplasia (BPD) is a chronic lung disease of prematurity, which affects
very preterm infants. Advances in perinatal care have enabled the survival of infants born as …