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[HTML][HTML] The impact of VEGF on cancer metastasis and systemic disease
Metastasis is the leading cause of cancer-associated mortality and the underlying
mechanisms of cancer metastasis remain elusive. Both blood and lymphatic vasculatures …
mechanisms of cancer metastasis remain elusive. Both blood and lymphatic vasculatures …
The mechanisms of nanoparticle delivery to solid tumours
LNM Nguyen, W Ngo, ZP Lin, S Sindhwani… - Nature Reviews …, 2024 - nature.com
Nanoparticles for the detection and treatment of cancer have suffered from limited clinical
translation. A key problem has been the lack of understanding of the mechanisms of …
translation. A key problem has been the lack of understanding of the mechanisms of …
The exit of nanoparticles from solid tumours
LNM Nguyen, ZP Lin, S Sindhwani, P MacMillan… - Nature Materials, 2023 - nature.com
Nanoparticles enter tumours through endothelial cells, gaps or other mechanisms, but how
they exit is unclear. The current paradigm states that collapsed tumour lymphatic vessels …
they exit is unclear. The current paradigm states that collapsed tumour lymphatic vessels …
Intravital imaging to study cancer progression and metastasis
D Entenberg, MH Oktay, JS Condeelis - Nature Reviews Cancer, 2023 - nature.com
Navigation through the bulk tumour, entry into the blood vasculature, survival in the
circulation, exit at distant sites and resumption of proliferation are all steps necessary for …
circulation, exit at distant sites and resumption of proliferation are all steps necessary for …
Lymphatic vessels in cancer
The lymphatic system, composed of initial and collecting lymphatic vessels as well as lymph
nodes that are present in almost every tissue of the human body, acts as an essential …
nodes that are present in almost every tissue of the human body, acts as an essential …
Consensus guidelines for the use and interpretation of angiogenesis assays
P Nowak-Sliwinska, K Alitalo, E Allen, A Anisimov… - Angiogenesis, 2018 - Springer
The formation of new blood vessels, or angiogenesis, is a complex process that plays
important roles in growth and development, tissue and organ regeneration, as well as …
important roles in growth and development, tissue and organ regeneration, as well as …
Lymphatic vessels in the age of cancer immunotherapy
T Karakousi, T Mudianto, AW Lund - Nature Reviews Cancer, 2024 - nature.com
Lymphatic transport maintains homeostatic health and is necessary for immune surveillance,
and yet lymphatic growth is often associated with solid tumour development and …
and yet lymphatic growth is often associated with solid tumour development and …
Solid stress and elastic energy as measures of tumour mechanopathology
Solid stress and tissue stiffness affect tumour growth, invasion, metastasis and treatment.
Unlike stiffness, which can be precisely mapped in tumours, the measurement of solid …
Unlike stiffness, which can be precisely mapped in tumours, the measurement of solid …
The role of mechanical forces in tumor growth and therapy
RK Jain, JD Martin… - Annual review of …, 2014 - annualreviews.org
Tumors generate physical forces during growth and progression. These physical forces are
able to compress blood and lymphatic vessels, reducing perfusion rates and creating …
able to compress blood and lymphatic vessels, reducing perfusion rates and creating …
Lymphangiogenesis and lymphatic vessel remodelling in cancer
SA Stacker, SP Williams, T Karnezis, R Shayan… - Nature Reviews …, 2014 - nature.com
The generation of new lymphatic vessels through lymphangiogenesis and the remodelling
of existing lymphatics are thought to be important steps in cancer metastasis. The past …
of existing lymphatics are thought to be important steps in cancer metastasis. The past …