The centromere is a chromosomal locus that ensures delivery of one copy of each
chromosome to each daughter at cell division. Efforts to understand the nature and …

In all eukaryotes, a microtubule-based structure known as the spindle is responsible for
accurate chromosome segregation during cell division. Spindle assembly and function …

To address questions about mechanisms of filament-based organelle transport, a system
was developed to image and track mitochondria in an intact Drosophila nervous system …

We discovered that many proteins located in the kinetochore outer domain, but not the inner
core, are depleted from kinetochores and accumulate at spindle poles when ATP production …

Dynein at the cortex contributes to microtubule-based positioning processes such as spindle
positioning during embryonic cell division and centrosome positioning during fibroblast …

Chromosome segregation is a complex and astonishingly accurate process whose inner
working is beginning to be understood at the molecular level. The spindle checkpoint plays …

All eukaryotic cells prepare for cell division by forming a “mitotic spindle”—a bipolar machine
made from microtubules (MTs) and many associated proteins. This device organizes the …

After fusion of the viral envelope with the plasma membrane, herpes simplex virus type 1
(HSV1) capsids are transported along microtubules (MTs) from the cell periphery to the …

Cytoplasmic dynein has long been thought to be responsible for retrograde axonal transport.
As the number of cellular roles for this multifunctional protein has expanded, the complexity …

For over a century, scientists have strived to understand the mechanisms that govern the
accurate segregation of chromosomes during mitosis. The most intriguing feature of this …