Nitric oxide and peroxynitrite in health and disease
P Pacher, JS Beckman, L Liaudet - Physiological reviews, 2007 - journals.physiology.org
The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …
Peroxynitrite: biochemistry, pathophysiology and development of therapeutics
C Szabó, H Ischiropoulos, R Radi - Nature reviews Drug discovery, 2007 - nature.com
Peroxynitrite—the product of the diffusion-controlled reaction of nitric oxide with superoxide
radical—is a short-lived oxidant species that is a potent inducer of cell death. Conditions in …
radical—is a short-lived oxidant species that is a potent inducer of cell death. Conditions in …
Progressive multiple sclerosis: pathology and pathogenesis
H Lassmann, J Van Horssen, D Mahad - Nature Reviews Neurology, 2012 - nature.com
Major progress has been made during the past three decades in understanding the
inflammatory process and pathogenetic mechanisms in multiple sclerosis (MS) …
inflammatory process and pathogenetic mechanisms in multiple sclerosis (MS) …
Multiple sclerosis: an immune or neurodegenerative disorder?
BD Trapp, KA Nave - Annu. Rev. Neurosci., 2008 - annualreviews.org
Multiple sclerosis (MS) is an inflammatory-mediated demyelinating disease of the human
central nervous system. The clinical disease course is variable, usually starts with reversible …
central nervous system. The clinical disease course is variable, usually starts with reversible …
Oxidative damage in multiple sclerosis lesions
Multiple sclerosis is a chronic inflammatory disease of the central nervous system,
associated with demyelination and neurodegeneration. The mechanisms of tissue injury are …
associated with demyelination and neurodegeneration. The mechanisms of tissue injury are …
NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury
Multiple sclerosis is a chronic inflammatory disease of the central nervous system,
associated with demyelination and neurodegeneration. The mechanisms of tissue injury are …
associated with demyelination and neurodegeneration. The mechanisms of tissue injury are …
The contribution of astrocytes to the neuroinflammatory response in multiple sclerosis and experimental autoimmune encephalomyelitis
R Brambilla - Acta neuropathologica, 2019 - Springer
Neuroinflammation is the coordinated response of the central nervous system (CNS) to
threats to its integrity posed by a variety of conditions, including autoimmunity, pathogens …
threats to its integrity posed by a variety of conditions, including autoimmunity, pathogens …
The physiology and pathophysiology of nitric oxide in the brain
Nitric oxide (NO) is a molecule with pleiotropic effects in different tissues. NO is synthesized
by NO synthases (NOS), a family with four major types: endothelial, neuronal, inducible and …
by NO synthases (NOS), a family with four major types: endothelial, neuronal, inducible and …
Implications of glial nitric oxide in neurodegenerative diseases
JE Yuste, E Tarragon, CM Campuzano… - Frontiers in cellular …, 2015 - frontiersin.org
Nitric oxide (NO) is a pleiotropic janus-faced molecule synthesized by nitric oxide synthases
(NOS) which plays a critical role in a number of physiological and pathological processes in …
(NOS) which plays a critical role in a number of physiological and pathological processes in …
Mechanisms of neuronal dysfunction and degeneration in multiple sclerosis
R Dutta, BD Trapp - Progress in neurobiology, 2011 - Elsevier
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system. Due to its high prevalence, MS is the leading cause of non-traumatic …
nervous system. Due to its high prevalence, MS is the leading cause of non-traumatic …