Osteomyelitis is a devastating disease caused by microbial infection in deep bone tissue. Its
high recurrence rate and impaired restoration of bone deficiencies are major challenges in …

Biomaterial‐mediated inflammation and fibrosis remain a prominent challenge in designing
materials to support tissue repair and regeneration. Despite the many biomaterial …

A coordinated interaction between osteogenesis and osteoimmune microenvironment is
essential for successful bone healing. In particular, macrophages play a central regulatory …

Various artificial bone graft substitutes based on ceramics have been developed over the
last 20 years. Among them, calcium-silicate-based ceramics, which are osteoconductive and …

Bone metabolism is tightly regulated by the immune system. Accelerated bone destruction is
observed in many bone diseases, such as rheumatoid arthritis, fracture, and particle …

The regulatory role of the immune system in maintaining bone homeostasis and restoring its
functionality, when disturbed due to trauma or injury, has become evident in recent years …

Recent research in the vaccine and immunotherapy fields has revealed that biomaterials
have the ability to activate immune pathways, even in the absence of other immune …

Fracture healing is a complex biological process that involves the orchestrated interplay of
various cells and molecular signaling pathways. Among the key players, macrophages have …

Pores play a crucial role in bone regeneration as they allow the exchange of nutrition and
oxygen, expulsion of waste products, and bone tissue and vascular ingrowth through the …

The application of engineered biomaterials for wound healing has been pursued since the
beginning of tissue engineering. Here, we attempt to apply functionalized lignin to confer …