The pancreas is an endoderm-derived glandular organ that participates in the regulation of
systemic glucose metabolism and food digestion through the function of its endocrine and …

Diabetes has been a worldwide healthcare problem for many years. Current methods of
treating diabetes are still largely directed at symptoms, aiming to control the manifestations …

Adult somatic tissues have proven difficult to expand in vitro, largely because of the
complexity of recreating appropriate environmental signals in culture. We have overcome …

Understanding pancreas development can provide clues for better treatments of pancreatic
diseases. However, the molecular heterogeneity and developmental trajectory of the early …

Single-cell genomic technologies enable the multimodal profiling of millions of cells across
temporal and spatial dimensions. However, experimental limitations hinder the …

The pancreas originates from two epithelial evaginations of the foregut, which consist of
multipotent epithelial progenitors that organize into a complex tubular epithelial network …

Many embryonic organs undergo epithelial morphogenesis to form tree-like hierarchical
structures. However, it remains unclear what drives the budding and branching of stratified …

Postnatal maintenance or regeneration of pancreatic beta cells is considered to occur
exclusively via the replication of existing beta cells, but clinically meaningful restoration of …

Organogenesis requires the complex interactions of multiple cell lineages that coordinate
their expansion, differentiation, and maturation over time. Here, we profile the cell types …

Embryonic development relies on the capacity of progenitor cells to appropriately respond to
inductive cues, a cellular property known as developmental competence. Here, we report …