Synovial fluid is a viscous solution found in the cavities of synovial joints. The principal role
of synovial fluid is to reduce friction between the articular cartilages of synovial joints during …

The synovial joint contains synovial fluid (SF) within a cavity bounded by articular cartilage
and synovium. SF is a viscous fluid that has lubrication, metabolic, and regulatory functions …

Aging is a main risk factor for osteoarthritis (OA). FoxO transcription factors protect against
cellular and organismal aging, and FoxO expression in cartilage is reduced with aging and …

Using a surface force apparatus, we have measured the normal and friction forces between
layers of the human glycoprotein lubricin, the major boundary lubricant in articular joints …

Mediterranean diet includes a relatively high fat consumption mostly from monounsaturated
fatty acids mainly provided by olive oil, the principal source of culinary and dressing fat. The …

The synovial fluid (SF) of joints normally functions as a biological lubricant, providing low-
friction and low-wear properties to articulating cartilage surfaces through the putative …

Despite continuous progress toward tissue engineering of functional articular cartilage,
significant challenges still remain. Advances in morphogens, stem cells, and scaffolds have …

Lubricin is a secreted, cytoprotective glycoprotein that contributes to the essential boundary
lubrication mechanisms necessary for maintaining low friction levels at articular cartilage …

Human synovial joints display a characteristic anatomic distribution of arthritis, eg
rheumatoid arthritis primarily affects the metacarpophalangeal and proximal finger joints, but …

Objective To assess the role of the glycoprotein PRG4 in joint lubrication and
chondroprotection by measuring friction, stiffness, surface topography, and subsurface …