Multiple sclerosis and cognition: synaptic failure and network dysfunction

M Di Filippo, E Portaccio, A Mancini… - Nature Reviews …, 2018 - nature.com
Cognitive impairment is increasingly recognized to be a core feature of multiple sclerosis
(MS), with important implications for the everyday life of individuals with MS and for disease …

Cortical neurons exhibit diverse myelination patterns that scale between mouse brain regions and regenerate after demyelination

CL Call, DE Bergles - Nature communications, 2021 - nature.com
Axons in the cerebral cortex show a broad range of myelin coverage. Oligodendrocytes
establish this pattern by selecting a cohort of axons for myelination; however, the distribution …

A systematic review of discrete-choice experiments and conjoint analysis studies in people with multiple sclerosis

EJD Webb, D Meads, I Eskyte, N King… - The Patient-Patient …, 2018 - Springer
Background Multiple sclerosis (MS) is a chronic disabling, inflammatory, and degenerative
disease of the central nervous system that, in most cases, requires long-term disease …

Serum neurofilament light and MRI predictors of cognitive decline in patients with secondary progressive multiple sclerosis: Analysis from the MS-STAT randomised …

T Williams, C Tur, A Eshaghi, A Doshi… - Multiple Sclerosis …, 2022 - journals.sagepub.com
Background: Cognitive impairment affects 50%–75% of people with secondary progressive
multiple sclerosis (PwSPMS). Improving our ability to predict cognitive decline may facilitate …

Structural network disruption markers explain disability in multiple sclerosis

T Charalambous, C Tur, F Prados, B Kanber… - Journal of Neurology …, 2019 - jnnp.bmj.com
Objective To evaluate whether structural brain network metrics correlate better with clinical
impairment and information processing speed in multiple sclerosis (MS) beyond atrophy …

Deep grey matter MRI abnormalities and cognitive function in relapsing-remitting multiple sclerosis

L Debernard, TR Melzer, S Alla, J Eagle… - Psychiatry Research …, 2015 - Elsevier
Although deep grey matter (GM) involvement in multiple sclerosis (MS) is well documented,
in-vivo multi-parameter magnetic resonance imaging (MRI) studies and association with …

Hippocampal and limbic microstructure changes associated with stress across the lifespan: a UK biobank study

E McManus, H Haroon, NW Duncan, R Elliott… - Scientific Reports, 2024 - nature.com
Experiencing highly stressful events can have detrimental and lasting effects on brain
morphology. The current study explores the effects of stress during childhood and adulthood …

Alterations in gray matter volume due to unilateral hearing loss

X Wang, P Xu, P Li, Z Wang, F Zhao, Z Gao, L Xu… - Scientific Reports, 2016 - nature.com
Although extensive research on neural plasticity resulting from hearing deprivation has been
conducted, the direct influence of compromised audition on the auditory cortex and the …

Inflammatory natalizumab-associated PML: baseline characteristics, lesion evolution and relation with PML-IRIS

MP Wattjes, MT Wijburg, J van Eijk… - Journal of Neurology …, 2018 - jnnp.bmj.com
Background and objective Natalizumab-associated progressive multifocal
leukoencephalopathy (NTZ-PML) patients may show imaging signs suggestive of …

DIR-visible grey matter lesions and atrophy in multiple sclerosis: partners in crime?

SHP van de Pavert, N Muhlert, V Sethi… - Journal of Neurology …, 2016 - jnnp.bmj.com
Background The extent and clinical relevance of grey matter (GM) pathology in multiple
sclerosis (MS) are increasingly recognised. GM pathology may present as focal lesions …