Targeted nucleases have provided researchers with the ability to manipulate virtually any
genomic sequence, enabling the facile creation of isogenic cell lines and animal models for …

Protein/antibody therapeutics have exhibited the advantages of high specificity and activity
even at an extremely low concentration compared to small molecule drugs. However, they …

Protein-based therapeutics have made a significant impact in the treatment of a variety of
important human diseases. However, given their intrinsically vulnerable structure and …

Targeted nucleases, including zinc-finger nucleases (ZFNs), transcription activator-like
(TAL) effector nucleases (TALENs) and clustered regularly interspaced short palindromic …

Biomolecules have many properties that make them promising for intracellular therapeutic
applications, but delivery remains a key challenge because large biomolecules cannot …

DNA and RNA play pivotal roles in life processes by storing and transferring genetic
information, modulating gene expression, and contributing to essential cellular machinery …

Realizing the full potential of genome editing requires the development of efficient and
broadly applicable methods for delivering programmable nucleases and donor templates for …

Stimuli‐responsive molecular containers are of great importance for controlled drug delivery
and other biomedical applications. A new type of acid labile acyclic cucurbit [n] uril (CB [n]) …

Studying functional protein delivery into live cells is important, ranging from fundamental
research to therapeutics. Cell-penetrating peptides (CPPs) are known to deliver proteins …

The recent Middle East respiratory syndrome coronavirus (MERS-CoV), Ebola and Zika
virus outbreaks exemplify the continued threat of (re-) emerging viruses to human health …