Mechanisms of mitochondrial respiratory adaptation
Mitochondrial energetic adaptations encompass a plethora of conserved processes that
maintain cell and organismal fitness and survival in the changing environment by adjusting …
maintain cell and organismal fitness and survival in the changing environment by adjusting …
Organization and expression of the mammalian mitochondrial genome
O Rackham, A Filipovska - Nature Reviews Genetics, 2022 - nature.com
The mitochondrial genome encodes core subunits of the respiratory chain that drives
oxidative phosphorylation and is, therefore, essential for energy conversion. Advances in …
oxidative phosphorylation and is, therefore, essential for energy conversion. Advances in …
Mechanisms and regulation of protein synthesis in mitochondria
E Kummer, N Ban - Nature Reviews Molecular Cell Biology, 2021 - nature.com
Mitochondria are cellular organelles responsible for generation of chemical energy in the
process called oxidative phosphorylation. They originate from a bacterial ancestor and …
process called oxidative phosphorylation. They originate from a bacterial ancestor and …
[HTML][HTML] Getting out what you put in: Copper in mitochondria and its impacts on human disease
Mitochondria accumulate copper in their matrix for the eventual maturation of the
cuproenzymes cytochrome c oxidase and superoxide dismutase. Transport into the matrix is …
cuproenzymes cytochrome c oxidase and superoxide dismutase. Transport into the matrix is …
A high-density human mitochondrial proximity interaction network
H Antonicka, ZY Lin, A Janer, MJ Aaltonen… - Cell metabolism, 2020 - cell.com
We used BioID, a proximity-dependent biotinylation assay with 100 mitochondrial baits from
all mitochondrial sub-compartments, to create a high-resolution human mitochondrial …
all mitochondrial sub-compartments, to create a high-resolution human mitochondrial …
[HTML][HTML] Mitochondrial OXPHOS biogenesis: co-regulation of protein synthesis, import, and assembly pathways
The assembly of mitochondrial oxidative phosphorylation (OXPHOS) complexes is an
intricate process, which—given their dual-genetic control—requires tight co-regulation of two …
intricate process, which—given their dual-genetic control—requires tight co-regulation of two …
[HTML][HTML] Identification of TMEM126A as OXA1L-interacting protein reveals cotranslational quality control in mitochondria
S Poerschke, S Oeljeklaus, LD Cruz-Zaragoza… - Molecular cell, 2024 - cell.com
Cellular proteostasis requires transport of polypeptides across membranes. Although
defective transport processes trigger cytosolic rescue and quality control mechanisms that …
defective transport processes trigger cytosolic rescue and quality control mechanisms that …
Cooperative assembly of the mitochondrial respiratory chain
E Fernández-Vizarra, C Ugalde - Trends in Biochemical Sciences, 2022 - cell.com
Deep understanding of the pathophysiological role of the mitochondrial respiratory chain
(MRC) relies on a well-grounded model explaining how its biogenesis is regulated. The lack …
(MRC) relies on a well-grounded model explaining how its biogenesis is regulated. The lack …
Coordinating mitochondrial translation with assembly of the OXPHOS complexes
The mitochondrial oxidative phosphorylation (OXPHOS) system produces the majority of
energy required by cells. Given the mitochondrion's endosymbiotic origin, the OXPHOS …
energy required by cells. Given the mitochondrion's endosymbiotic origin, the OXPHOS …
[HTML][HTML] Early fate decision for mitochondrially encoded proteins by a molecular triage
Folding of newly synthesized proteins poses challenges for a functional proteome.
Dedicated protein quality control (PQC) systems either promote the folding of nascent …
Dedicated protein quality control (PQC) systems either promote the folding of nascent …