Despite the generally held view that alcohol is an unspecific pharmacological agent, recent
molecular pharmacology studies demonstrated that alcohol has only a few known primary …

The past two decades have witnessed a dramatic accumulation of evidence indicating that
the excitatory amino acid glutamate plays an important role in drug addiction and …

Orexin-containing neurons have been implicated in feeding, sleep–wake cycles and more
recently in drug-seeking behaviour. Pretreatment of alcohol-preferring (iP) rats with an …

Rationale An increasingly compelling literature points to a major role for the glutamate
system in mediating the effects of alcohol on behavior and the pathophysiology of …

Depression and anxiety represent a major problem. However, the current treatment of both
groups of diseases is not satisfactory. As the glutamatergic system may play an important …

There is now compelling evidence that the excitatory amino acid neurotransmitter glutamate
plays a pivotal role in drug addiction and alcoholism. As a result, there has been increasing …

Medicinal therapies for mood disorders neither fully serve the efficacy needs of patients nor
are they free of side-effect issues. Although monoamine-based therapies are the primary …

Emerging evidence demonstrates that alcohol dependence is associated with dysregulation
of several neurotransmitters. Alterations in dopamine, glutamate and gamma-aminobutyric …

Emerging evidence indicates that dysfunctional glutamate neurotransmission is critical in the
initiation and development of alcohol and drug dependence. Alcohol consumption induced …

Aims: Changes in glutamatergic transmission affect many aspects of neuroplasticity
associated with ethanol and drug addiction. For instance, ethanol-and drug-seeking …