Indication and management of allogeneic haematopoietic stem-cell transplantation in myelofibrosis: updated recommendations by the EBMT/ELN International …

N Kröger, A Bacigalupo, T Barbui… - The Lancet …, 2024 - thelancet.com
New options for medical therapy and risk scoring systems containing molecular data are
leading to increased complexity in the management of patients with myelofibrosis. To inform …

Novel developments in the prophylaxis and treatment of acute GVHD

O Jamy, R Zeiser, YB Chen - Blood, 2023 - ashpublications.org
Acute graft-versus-host disease (aGVHD) is a major life-threatening complication after
allogeneic hematopoietic cell transplant. Traditional standard prophylaxis for aGVHD has …

Vedolizumab for the prevention of intestinal acute GVHD after allogeneic hematopoietic stem cell transplantation: a randomized phase 3 trial

YB Chen, M Mohty, R Zeiser, T Teshima, O Jamy… - Nature medicine, 2024 - nature.com
Acute graft-versus-host disease (aGVHD) of the lower gastrointestinal (GI) tract is a major
cause of morbidity and mortality in patients receiving allogeneic hematopoietic stem cell …

Post-transplant cyclophosphamide–based graft-versus-host disease prophylaxis attenuates disparity in outcomes between use of matched or mismatched unrelated …

BC Shaffer, M Gooptu, TE DeFor, M Maiers… - Journal of Clinical …, 2024 - ascopubs.org
PURPOSE Access to allogeneic hematopoietic cell transplantation (HCT) remains limited
among persons of non-European ancestry if human leukocyte antigen (HLA) matching is …

PTCy versus ATG as graft-versus-host disease prophylaxis in mismatched unrelated stem cell transplantation

O Penack, M Abouqateb, C Peczynski… - Blood Cancer …, 2024 - nature.com
There is an increased risk of GVHD and of non-relapse mortality (NRM) after allogeneic
stem cell transplantations (alloSCT) when mismatched unrelated donors (MMUD) are used …

ATG or post-transplant cyclophosphamide to prevent GVHD in matched unrelated stem cell transplantation?

O Penack, M Abouqateb, C Peczynski, W Boreland… - Leukemia, 2024 - nature.com
There is a high risk of GVHD and non-relapse mortality (NRM) after allogeneic stem cell
transplantations (alloSCT) from unrelated donors. Prophylaxis with rabbit anti-thymocyte …

Younger unrelated donors may be preferable over HLA match in the PTCy era: a study from the ALWP of the EBMT

J Sanz, M Labopin, G Choi, A Kulagin, J Peccatori… - Blood, 2024 - ashpublications.org
There is a paucity of information on how to select the most appropriate unrelated donor (UD)
in hematopoietic stem cell transplantation (HSCT) using posttransplant cyclophosphamide …

Human leukocyte antigen mismatching and survival in contemporary hematopoietic cell transplantation for hematologic malignancies

E Arrieta-Bolaños, EF Bonneville, P Crivello… - Journal of Clinical …, 2024 - ascopubs.org
PURPOSE Human leukocyte antigen (HLA) mismatching can reduce survival of patients
with blood cancer after hematopoietic cell transplantation (HCT). How recent advances in …

[HTML][HTML] Current approaches for the prevention and treatment of acute and chronic GVHD

A Olivieri, G Mancini - Cells, 2024 - mdpi.com
Whereas aGVHD has strong inflammatory components, cGVHD displays autoimmune and
fibrotic features; incidence and risk factors are similar but not identical; indeed, the aGVHD is …

Prophylactic maintenance with venetoclax/azacitidine after reduced-intensity conditioning allogeneic transplant for high-risk MDS and AML

JS Garcia, HT Kim, HM Murdock, M Ansuinelli… - Blood …, 2024 - ashpublications.org
We conducted a phase 1 trial assessing safety and efficacy of prophylactic maintenance
therapy with venetoclax and azacitidine (Ven/Aza) for patients with high-risk myelodysplastic …