Reactive oxygen species (ROS) are key signaling molecules that play an important role in
the progression of inflammatory disorders. An enhanced ROS generation by …

The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

In vitro models that better reflect in vivo epithelial barrier (patho-) physiology are urgently
required to predict adverse drug effects. Here we introduce extracellular matrix-supported …

Intercellular junctions mediate adhesion and communication between adjoining endothelial
and epithelial cells. In the endothelium, junctional complexes comprise tight junctions …

The endothelial monolayer partitioning underlying tissue from blood components in the
vessel wall maintains tissue fluid balance and host defense through dynamically opening …

Endothelial cells lining the vessel wall are connected by adherens, tight and gap junctions.
These junctional complexes are related to those found at epithelial junctions but with …

Inflammatory recruitment of leukocytes is governed by dynamic interactions between
integrins and endothelial immunoglobulin superfamily (IgSF) proteins. We have identified …

The coxsackievirus and adenovirus receptor (CAR) mediates viral attachment and infection,
but its physiologic functions have not been described. In nonpolarized cells, CAR localized …

Junctional adhesion molecules (JAMs) are members of an immunoglobulin subfamily
expressed by leukocytes and platelets as well as by epithelial and endothelial cells, in which …

Junctional adhesion molecules (JAM)-A,-B and-C are cell-cell adhesion molecules of the
immunoglobulin superfamily which are expressed by a variety of tissues, both during …