Problematic alcohol use (PAU), a trait that combines alcohol use disorder and alcohol-
related problems assessed with a questionnaire, is a leading cause of death and morbidity …

Chronic pain is a common problem, with more than one-fifth of adult Americans reporting
pain daily or on most days. It adversely affects the quality of life and imposes substantial …

Tobacco use disorder (TUD) is the most prevalent substance use disorder in the world.
Genetic factors influence smoking behaviours and although strides have been made using …

Substance use disorders represent a significant public health concern with considerable
socioeconomic implications worldwide. Twin and family-based studies have long …

Excessive substance use and substance use disorders (SUDs) are common, serious and
relapsing medical conditions. They frequently co-occur with other diseases that are leading …

Adverse childhood events (ACEs) contribute to the development of mood and anxiety
disorders and substance dependence. However, the extent to which these effects are direct …

Abstract Background and Aims Genome‐wide association studies (GWAS) of opioid use
disorder (OUD) and cannabis use disorder (CUD) have lagged behind those of alcohol use …

Substance use disorders (SUDs) are highly prevalent and associated with excess morbidity,
mortality, and economic costs. Thus, there is considerable interest in the early identification …

To characterize polysubstance addiction (PSA) patterns of cocaine use disorder (CoUD), we
performed a latent class analysis (LCA) in 7,989 participants with a lifetime DSM-5 diagnosis …

Abstract Background and Aims Genetic risk can influence disease progression. We
measured the impact of genetic risk for substance use disorders (SUDs) on substance use …