The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …

Conspectus Glycosaminoglycans (GAGs) are a family of structurally complex
heteropolysaccharides composed of alternating hexosamine and uronic acid or galatose …

Heparin and heparan sulfate glycosaminoglycans are long, linear polysaccharides that are
made up of alternating dissacharide sequences of sulfated uronic acid and amino sugars …

Heparan sulfates (HS) are linear sulfated polysaccharides that modulate a wide range of
physiological and disease-processes. Variations in HS epimerization and sulfation provide …

Heparin (HP) and heparan sulfate (HS) are linear, anionically charged polysaccharides well-
known for their diverse biological activities. While HP is generally localized in mast cells and …

Conspectus Carbohydrates are called the third chain of life. Carbohydrates participate in
many important biochemical functions in living species, and the biological information …

Heparin and heparan sulfate represent key members of the glycosaminoglycan family of
carbohydrates and underpin considerable repertoires of biological importance. As such …

More than 3000 proteins are now known to bind to glycosaminoglycans (GAGs). Yet, GAG–
protein systems are rather poorly understood in terms of selectivity of recognition, molecular …

Heparan sulfate (HS) has multifaceted biological activities. To date, no libraries of HS
oligosaccharides bearing systematically varied sulfation structures are available owing to …

Heparin (H) and heparan sulfate (HS) belong to the glycosaminoglycan (GAG) family of
oligosaccharides, and their sequences and sulfation patterns are known to regulate the …