Therapy with oncolytic viruses: progress and challenges

SZ Shalhout, DM Miller, KS Emerick… - Nature reviews Clinical …, 2023 - nature.com
Oncolytic viruses (OVs) are an emerging class of cancer therapeutics that offer the benefits
of selective replication in tumour cells, delivery of multiple eukaryotic transgene payloads …

Dendritic cell subsets in cancer immunity and tumor antigen sensing

A Del Prete, V Salvi, A Soriani, M Laffranchi… - Cellular & molecular …, 2023 - nature.com
Dendritic cells (DCs) exhibit a specialized antigen-presenting function and play crucial roles
in both innate and adaptive immune responses. Due to their ability to cross-present tumor …

Immunogenic cell stress and death

G Kroemer, C Galassi, L Zitvogel, L Galluzzi - Nature immunology, 2022 - nature.com
Dying mammalian cells emit numerous signals that interact with the host to dictate the
immunological correlates of cellular stress and death. In the absence of reactive antigenic …

Immunogenic cell death activates the tumor immune microenvironment to boost the immunotherapy efficiency

Z Li, X Lai, S Fu, L Ren, H Cai, H Zhang, Z Gu… - Advanced …, 2022 - Wiley Online Library
Tumor immunotherapy is only effective in a fraction of patients due to a low response rate
and severe side effects, and these challenges of immunotherapy in clinics can be addressed …

ZIF‐8 nanoparticles evoke pyroptosis for high‐efficiency cancer immunotherapy

B Ding, H Chen, J Tan, Q Meng… - Angewandte Chemie …, 2023 - Wiley Online Library
Although zeolitic imidazolate framework‐8 (ZIF‐8) has been applied in various tumor
therapies, the intrinsic immunogenicity remains unclear. Here, we initiatively discover that …

Metal-based photosensitizers as inducers of regulated cell death mechanisms

Y Zhang, BT Doan, G Gasser - Chemical Reviews, 2023 - ACS Publications
Over the last few decades, various forms of regulated cell death (RCD) have been
discovered and were found to improve cancer treatment. Although there are several reviews …

A photo-triggered self-accelerated nanoplatform for multifunctional image-guided combination cancer immunotherapy

X Kang, Y Zhang, J Song, L Wang, W Li, J Qi… - Nature …, 2023 - nature.com
Precise and efficient image-guided immunotherapy holds great promise for cancer
treatment. Here, we report a self-accelerated nanoplatform combining an aggregation …

Inflammation and tumor progression: signaling pathways and targeted intervention

H Zhao, L Wu, G Yan, Y Chen, M Zhou… - Signal transduction and …, 2021 - nature.com
Cancer development and its response to therapy are regulated by inflammation, which
either promotes or suppresses tumor progression, potentially displaying opposing effects on …

Immunogenic cell death inducing metal complexes for cancer therapy

L Zhang, N Montesdeoca, J Karges… - Angewandte Chemie …, 2023 - Wiley Online Library
Cancer is one of the deadliest diseases worldwide. Recent statistics have shown that
metastases and tumor relapse are the leading causes of cancer‐associated deaths. While …

Pyroptosis‐Mediated Synergistic Photodynamic and Photothermal Immunotherapy Enabled by a Tumor‐Membrane‐Targeted Photosensitive Dimer

Y Tang, HK Bisoyi, XM Chen, Z Liu, X Chen… - Advanced …, 2023 - Wiley Online Library
Overcoming the resistance to apoptosis and immunosuppression of tumor cells is a
significant challenge in augmenting the effect of cancer immunotherapy. Pyroptosis, a lytic …