Abstract p53 functions as a transcription factor involved in cell-cycle control, DNA repair,
apoptosis and cellular stress responses. However, besides inducing cell growth arrest and …

The presence of ROS is a constant feature in living cells metabolizing O2. ROS
concentration and compartmentation determine their physiological or pathological effects …

Sirtuins are a class of NAD+-dependent deacetylases having beneficial health effects. This
extensive review describes the numerous intracellular actions of the seven mammalian …

Abstract Sirtuin 3 (Sirt3), a major mitochondrial NAD+-dependent deacetylase, targets
various mitochondrial proteins for lysine deacetylation and regulates important cellular …

Aims: Our previous clinical trial indicated that the flavonoid dihydromyricetin (DHM) could
improve hepatic steatosis in patients with nonalcoholic fatty liver disease (NAFLD), altough …

Background Cancer cells possess a common metabolic phenotype, rewiring their metabolic
pathways from mitochondrial oxidative phosphorylation to aerobic glycolysis and anabolic …

Aims: Parkinson's disease (PD) heavily affects humans and little is known about its cause
and pathogenesis. Sirtuin 3 (Sirt3) plays a key role in regulating mitochondrial dysfunction …

Doxorubicin (DOX) is a potent anthracycline antineoplastic drug. However, its dose-
dependent cardiotoxicity limits its clinical application. Ononin is a natural isoflavone …

Oxidative stress induced post-translational protein modifications are associated with the
development of inflammatory hypersensitivities. At least 90% of cellular reactive oxygen …

The energy production and metabolic homeostasis are well-orchestrated networks of
carbohydrate, lipid and protein metabolism. These metabolic pathways are integrated by a …