Single-molecule force spectroscopy: optical tweezers, magnetic tweezers and atomic force microscopy
Single-molecule force spectroscopy has emerged as a powerful tool to investigate the forces
and motions associated with biological molecules and enzymatic activity. The most common …
and motions associated with biological molecules and enzymatic activity. The most common …
Fibrin formation, structure and properties
Fibrinogen and fibrin are essential for hemostasis and are major factors in thrombosis,
wound healing, and several other biological functions and pathological conditions. The X …
wound healing, and several other biological functions and pathological conditions. The X …
Fibrin clot structure and function: a role in the pathophysiology of arterial and venous thromboembolic diseases
A Undas, RAS Ariëns - Arteriosclerosis, thrombosis, and vascular …, 2011 - Am Heart Assoc
The formation of fibrin clots that are relatively resistant to lysis represents the final step in
blood coagulation. We discuss the genetic and environmental regulators of fibrin structure in …
blood coagulation. We discuss the genetic and environmental regulators of fibrin structure in …
Fibrin mechanical properties and their structural origins
Fibrin is a protein polymer that is essential for hemostasis and thrombosis, wound healing,
and several other biological functions and pathological conditions that involve extracellular …
and several other biological functions and pathological conditions that involve extracellular …
Multiscale mechanics of fibrin polymer: gel stretching with protein unfolding and loss of water
Blood clots and thrombi consist primarily of a mesh of branched fibers made of the protein
fibrin. We propose a molecular basis for the marked extensibility and negative …
fibrin. We propose a molecular basis for the marked extensibility and negative …
Non-linear elasticity of extracellular matrices enables contractile cells to communicate local position and orientation
Most tissue cells grown in sparse cultures on linearly elastic substrates typically display a
small, round phenotype on soft substrates and become increasingly spread as the modulus …
small, round phenotype on soft substrates and become increasingly spread as the modulus …
Crystal structure of human fibrinogen
JM Kollman, L Pandi, MR Sawaya, M Riley… - Biochemistry, 2009 - ACS Publications
A crystal structure of human fibrinogen has been determined at approximately 3.3 Å
resolution. The protein was purified from human blood plasma, first by a cold ethanol …
resolution. The protein was purified from human blood plasma, first by a cold ethanol …
Discovery through the computational microscope
All-atom molecular dynamics simulations have become increasingly popular as a tool to
investigate protein function and dynamics. However, researchers are concerned about the …
investigate protein function and dynamics. However, researchers are concerned about the …
Finding the weakest link–exploring integrin-mediated mechanical molecular pathways
From the extracellular matrix to the cytoskeleton, a network of molecular links connects cells
to their environment. Molecules in this network transmit and detect mechanical forces, which …
to their environment. Molecules in this network transmit and detect mechanical forces, which …
PolySTAT-modified chitosan gauzes for improved hemostasis in external hemorrhage
Positively-charged chitosan gauzes stop bleeding from wounds by electrostatically
interacting with negatively-charged cell membranes of erythrocytes to cause erythrocyte …
interacting with negatively-charged cell membranes of erythrocytes to cause erythrocyte …