Prostate organogenesis is a complex process that is primarily mediated by the presence of
androgens and subsequent mesenchyme-epithelial interactions. The investigation of …

Cell signaling plays a key role in the development of all multicellular organisms. Numerous
studies have established the importance of Hedgehog signaling in a wide variety of …

Prostate cancer afflicts one man in nine over the age of 65 and represents the most
frequently diagnosed cancer in American men (Coffey 1993). Early detection through serum …

In aging men, the prostate gland becomes hyperproliferative and displays a propensity
toward carcinoma. Although this hyperproliferative process has been proposed to represent …

Abstract The Pathological Classification of Prostate Lesions in Genetically Engineered Mice
(GEM) is the result of a directive from the National Cancer Institute Mouse Models of Human …

The prostate is a male accessory sex gland found only in mammals that functions to produce
a major fraction of seminal fluid. Interest in understanding the biology of the prostate is …

Gene targeting experiments have shown that the murine Hoxa-13 and Hoxd-13 paralogous
genes control skeletal patterning in the distal region of the develo** limbs. However, both …

Hypospadias is one of the most common congenital anomalies in the United States,
occurring in approximately 1 in 250 newborns or roughly 1 in 125 live male births. It is the …

Mice deficient for theAbdominal B (AbdB) HoxgeneHoxa-10exhibit reduced fertility due to
defects in implantation. During the peri-implantation periodHoxa-10is sequentially …

Prostate gland development is a complex process that involves coordination of multiple
signaling pathways including endocrine, paracrine, autocrine, juxtacrine and transcription …