[HTML][HTML] Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation
The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …
components across multiple spatial (from ion channel to organ) and temporal (from …
Credibility assessment of in silico clinical trials for medical devices
In silico clinical trials (ISCTs) are an emerging method in modeling and simulation where
medical interventions are evaluated using computational models of patients. ISCTs have the …
medical interventions are evaluated using computational models of patients. ISCTs have the …
The openCARP simulation environment for cardiac electrophysiology
Abstract Background and Objective: Cardiac electrophysiology is a medical specialty with a
long and rich tradition of computational modeling. Nevertheless, no community standard for …
long and rich tradition of computational modeling. Nevertheless, no community standard for …
[HTML][HTML] A framework for the generation of digital twins of cardiac electrophysiology from clinical 12-leads ECGs
Abstract Cardiac digital twins (Cardiac Digital Twin (CDT) s) of human electrophysiology
(Electrophysiology (EP)) are digital replicas of patient hearts derived from clinical data that …
(Electrophysiology (EP)) are digital replicas of patient hearts derived from clinical data that …
Cell to whole organ global sensitivity analysis on a four-chamber heart electromechanics model using Gaussian processes emulators
Cardiac pump function arises from a series of highly orchestrated events across multiple
scales. Computational electromechanics can encode these events in physics-constrained …
scales. Computational electromechanics can encode these events in physics-constrained …
lifex-ep: a robust and efficient software for cardiac electrophysiology simulations
Background Simulating the cardiac function requires the numerical solution of multi-physics
and multi-scale mathematical models. This underscores the need for streamlined, accurate …
and multi-scale mathematical models. This underscores the need for streamlined, accurate …
Comparison of novel ventricular pacing strategies using an electro-mechanical simulation platform
Aims Focus of pacemaker therapy is shifting from right ventricular (RV) apex pacing (RVAP)
and biventricular pacing (BiVP) to conduction system pacing. Direct comparison between …
and biventricular pacing (BiVP) to conduction system pacing. Direct comparison between …
Effect of scar and His–Purkinje and myocardium conduction on response to conduction system pacing
Introduction Conduction system pacing (CSP), in the form of His bundle pacing (HBP) or left
bundle branch pacing (LBBP), is emerging as a valuable cardiac resynchronization therapy …
bundle branch pacing (LBBP), is emerging as a valuable cardiac resynchronization therapy …
Left bundle branch area pacing: implant technique, definitions, outcomes, and complications
Abstract Purpose of Review Conduction system pacing (CSP) has emerged during the last
few years as the cornerstone of physiological pacing. Two different CSP modalities have …
few years as the cornerstone of physiological pacing. Two different CSP modalities have …
[HTML][HTML] Biventricular endocardial pacing and left bundle branch area pacing for cardiac resynchronization: mechanistic insights from electrocardiographic imaging …
Background Biventricular endocardial pacing (BiV-endo) has demonstrated superior cardiac
resynchronization compared to conventional biventricular epicardial pacing (BiV-epi). Left …
resynchronization compared to conventional biventricular epicardial pacing (BiV-epi). Left …