Chronic rhinosinusitis is a common inflammatory disease of paranasal sinuses, which
causes rhinorrhea, nasal congestion, and hyposmia. The genetic predisposition or the …

Powerful bioinformatics tools have provided a wealth of novel miRNA–transcription factor
networks crucial in controlling gene regulation. In this review, we focus on the biological …

Bisphosphonates (BPs) are widely used to treat several metabolic and oncological diseases
affecting the skeletal system. Despite BPs' well-known therapeutic potential, they also …

Leukemias derived from the MLL-AF9 rearrangement rely on dysfunctional transcriptional
networks. ZNF521, a transcription co-factor implicated in the control of hematopoiesis, has …

The human zinc finger protein 521 (ZNF521) is a co-transcriptional factor with multiple
recognized regulatory functions in a range of normal, cancer and stem cell compartments …

To determine whether zinc finger protein 521 (Zfp521) has a chondroprotective effect by
maintaining extracellular matrix (ECM) homeostasis to attenuate osteoarthritis (OA). In …

ZNF521 is a transcription co-factor with recognized regulatory functions in haematopoietic,
osteo-adipogenic and neural progenitor cells. Among its diverse activities, ZNF521 has …

Background An essential element imbalance in the joint might favor gradual degeneration of
the articular cartilage. It has been reported that cadmium (Cd) plays an antagonistic role with …

Mesenchymal stem cells (MSCs) are multipotent progenitors present in the bone marrow
stroma and in subcutaneous abdominal fat, an abundant and easily accessible source of …

Preventive therapy can target hormone-responsive breast cancer (BC) by treatment with
selective estrogen receptor modulators (SERMs) and reduce the incidence of BC. Genome …