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Epidemiology and risk factors of melanoma
S Carr, C Smith, J Wernberg - Surgical Clinics, 2020 - surgical.theclinics.com
Melanoma is a potentially fatal skin malignancy that continues to increase in incidence
worldwide. The current lifetime risk of develo** melanoma is 1 in 63 in the United States …
worldwide. The current lifetime risk of develo** melanoma is 1 in 63 in the United States …
From melanocytes to melanomas
Melanomas on sun-exposed skin are heterogeneous tumours, which can be subtyped on
the basis of their cumulative levels of exposure to ultraviolet (UV) radiation. A melanocytic …
the basis of their cumulative levels of exposure to ultraviolet (UV) radiation. A melanocytic …
[HTML][HTML] NRAS mutant melanoma: Towards better therapies
T Randic, I Kozar, C Margue, J Utikal, S Kreis - Cancer treatment reviews, 2021 - Elsevier
Genetic alterations affecting RAS proteins are commonly found in human cancers. Roughly
a fourth of melanoma patients carry activating NRAS mutations, rendering this malignancy …
a fourth of melanoma patients carry activating NRAS mutations, rendering this malignancy …
Deleterious germline mutations in patients with apparently sporadic pancreatic adenocarcinoma
Purpose Deleterious germline mutations contribute to pancreatic cancer susceptibility and
are well documented in families in which multiple members have had pancreatic cancer …
are well documented in families in which multiple members have had pancreatic cancer …
Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility
Most genetic susceptibility to cutaneous melanoma remains to be discovered. Meta-analysis
genome-wide association study (GWAS) of 36,760 cases of melanoma (67% newly …
genome-wide association study (GWAS) of 36,760 cases of melanoma (67% newly …
Frequency of pathogenic germline variants in cancer-susceptibility genes in patients with osteosarcoma
Importance Osteosarcoma, the most common malignant bone tumor in children and
adolescents, occurs in a high number of cancer predisposition syndromes that are defined …
adolescents, occurs in a high number of cancer predisposition syndromes that are defined …
International Cancer of the Pancreas Screening (CAPS) Consortium summit on the management of patients with increased risk for familial pancreatic cancer
Background Screening individuals at increased risk for pancreatic cancer (PC) detects early,
potentially curable, pancreatic neoplasia. Objective To develop consortium statements on …
potentially curable, pancreatic neoplasia. Objective To develop consortium statements on …
Pancreatic ductal adenocarcinoma: risk factors, screening, and early detection
AE Becker, YG Hernandez, H Frucht… - World journal of …, 2014 - pmc.ncbi.nlm.nih.gov
Pancreatic cancer is the fourth most common cause of cancer-related deaths in the United
States, with over 38000 deaths in 2013. The opportunity to detect pancreatic cancer while it …
States, with over 38000 deaths in 2013. The opportunity to detect pancreatic cancer while it …
POT1 loss-of-function variants predispose to familial melanoma
Deleterious germline variants in CDKN2A account for around 40% of familial melanoma
cases, and rare variants in CDK4, BRCA2, BAP1 and the promoter of TERT have also been …
cases, and rare variants in CDK4, BRCA2, BAP1 and the promoter of TERT have also been …
Melanoma: What do all the mutations mean?
EJ Davis, DB Johnson, JA Sosman, S Chandra - Cancer, 2018 - Wiley Online Library
Melanoma is one of the most highly mutated malignancies, largely as a function of its
generation through ultraviolet light and other mutational processes. The wide array of …
generation through ultraviolet light and other mutational processes. The wide array of …