Epidemiology and risk factors of melanoma

S Carr, C Smith, J Wernberg - Surgical Clinics, 2020 - surgical.theclinics.com
Melanoma is a potentially fatal skin malignancy that continues to increase in incidence
worldwide. The current lifetime risk of develo** melanoma is 1 in 63 in the United States …

From melanocytes to melanomas

AH Shain, BC Bastian - nature reviews Cancer, 2016 - nature.com
Melanomas on sun-exposed skin are heterogeneous tumours, which can be subtyped on
the basis of their cumulative levels of exposure to ultraviolet (UV) radiation. A melanocytic …

[HTML][HTML] NRAS mutant melanoma: Towards better therapies

T Randic, I Kozar, C Margue, J Utikal, S Kreis - Cancer treatment reviews, 2021 - Elsevier
Genetic alterations affecting RAS proteins are commonly found in human cancers. Roughly
a fourth of melanoma patients carry activating NRAS mutations, rendering this malignancy …

Deleterious germline mutations in patients with apparently sporadic pancreatic adenocarcinoma

K Shindo, J Yu, M Suenaga… - Journal of Clinical …, 2017 - ascopubs.org
Purpose Deleterious germline mutations contribute to pancreatic cancer susceptibility and
are well documented in families in which multiple members have had pancreatic cancer …

Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility

MT Landi, DT Bishop, S MacGregor, MJ Machiela… - Nature …, 2020 - nature.com
Most genetic susceptibility to cutaneous melanoma remains to be discovered. Meta-analysis
genome-wide association study (GWAS) of 36,760 cases of melanoma (67% newly …

Frequency of pathogenic germline variants in cancer-susceptibility genes in patients with osteosarcoma

L Mirabello, B Zhu, R Koster, E Karlins, M Dean… - JAMA …, 2020 - jamanetwork.com
Importance Osteosarcoma, the most common malignant bone tumor in children and
adolescents, occurs in a high number of cancer predisposition syndromes that are defined …

International Cancer of the Pancreas Screening (CAPS) Consortium summit on the management of patients with increased risk for familial pancreatic cancer

MI Canto, F Harinck, RH Hruban, GJ Offerhaus… - Gut, 2013 - gut.bmj.com
Background Screening individuals at increased risk for pancreatic cancer (PC) detects early,
potentially curable, pancreatic neoplasia. Objective To develop consortium statements on …

Pancreatic ductal adenocarcinoma: risk factors, screening, and early detection

AE Becker, YG Hernandez, H Frucht… - World journal of …, 2014 - pmc.ncbi.nlm.nih.gov
Pancreatic cancer is the fourth most common cause of cancer-related deaths in the United
States, with over 38000 deaths in 2013. The opportunity to detect pancreatic cancer while it …

POT1 loss-of-function variants predispose to familial melanoma

CD Robles-Espinoza, M Harland, AJ Ramsay… - Nature …, 2014 - nature.com
Deleterious germline variants in CDKN2A account for around 40% of familial melanoma
cases, and rare variants in CDK4, BRCA2, BAP1 and the promoter of TERT have also been …

Melanoma: What do all the mutations mean?

EJ Davis, DB Johnson, JA Sosman, S Chandra - Cancer, 2018 - Wiley Online Library
Melanoma is one of the most highly mutated malignancies, largely as a function of its
generation through ultraviolet light and other mutational processes. The wide array of …