Allostery in homodimeric SARS-CoV-2 main protease
E Fornasier, S Fabbian, H Shehi, J Enderle… - Communications …, 2024 - nature.com
Many enzymes work as homodimers with two distant catalytic sites, but the reason for this
choice is often not clear. For the main protease Mpro of SARS-CoV-2, dimerization is …
choice is often not clear. For the main protease Mpro of SARS-CoV-2, dimerization is …
Mammalian Esterase Activity: Implications for Peptide Prodrugs
As a traceless, bioreversible modification, the esterification of carboxyl groups in peptides
and proteins has the potential to increase their clinical utility. An impediment is the lack of …
and proteins has the potential to increase their clinical utility. An impediment is the lack of …
Sensitive detection of SARS‐CoV‐2 main protease 3CLpro with an engineered ribonuclease zymogen
EC Wralstad, RT Raines - Protein Science, 2024 - Wiley Online Library
Alongside vaccines and antiviral therapeutics, diagnostic tools are a crucial aid in combating
the COVID‐19 pandemic caused by the etiological agent SARS‐CoV‐2. All common assays …
the COVID‐19 pandemic caused by the etiological agent SARS‐CoV‐2. All common assays …
Exploring and Exploiting Ribonuclease 1: from Protein Biochemistry to Protein Engineering
EC Wralstad - 2024 - dspace.mit.edu
Ribonuclease (RNase) 1 is a human protein with a remarkable ability to indiscriminately
hydrolyze RNA. RNase 1 and its bovine homologue RNase A exhibit ubiquitous expression …
hydrolyze RNA. RNase 1 and its bovine homologue RNase A exhibit ubiquitous expression …