Endometriosis is a chronic systemic disease: clinical challenges and novel innovations

HS Taylor, AM Kotlyar, VA Flores - The Lancet, 2021 - thelancet.com
Endometriosis is a common disease affecting 5–10% of women of reproductive age globally.
However, despite its prevalence, diagnosis is typically delayed by years, misdiagnosis is …

Rethinking mechanisms, diagnosis and management of endometriosis

C Chapron, L Marcellin, B Borghese… - Nature Reviews …, 2019 - nature.com
Endometriosis is a chronic inflammatory disease defined as the presence of endometrial
tissue outside the uterus, which causes pelvic pain and infertility. This disease should be …

Uterine bleeding: how understanding endometrial physiology underpins menstrual health

V Jain, RR Chodankar, JA Maybin… - Nature reviews …, 2022 - nature.com
Menstruation is a physiological process that is typically uncomplicated. However, up to one
third of women globally will be affected by abnormal uterine bleeding (AUB) at some point in …

Diagnosing adenomyosis: an integrated clinical and imaging approach

C Chapron, S Vannuccini, P Santulli… - Human reproduction …, 2020 - academic.oup.com
BACKGROUND Adenomyosis is a benign uterine disorder where endometrial glands and
stroma are pathologically demonstrated within the uterine myometrium. The pathogenesis …

[HTML][HTML] Pathogenesis of endometriosis: the genetic/epigenetic theory

PR Koninckx, A Ussia, L Adamyan, A Wattiez… - Fertility and sterility, 2019 - Elsevier
Objective To study the pathophysiology of endometriosis. Design Overview of observations
on endometriosis. Setting Not applicable. Patient (s) None. Interventions (s) None. Main …

Progesterone actions and resistance in gynecological disorders

JA MacLean, K Hayashi - Cells, 2022 - mdpi.com
Estrogen and progesterone and their signaling mechanisms are tightly regulated to maintain
a normal menstrual cycle and to support a successful pregnancy. The imbalance of estrogen …

[HTML][HTML] Recent advances in understanding and managing adenomyosis

S Vannuccini, F Petraglia - F1000Research, 2019 - ncbi.nlm.nih.gov
Adenomyosis is a benign uterine disorder in which endometrial glands and stroma are
pathologically demonstrated in the uterine myometrium and it is considered a specific entity …

[HTML][HTML] Pathogenesis of uterine adenomyosis: invagination or metaplasia?

J García-Solares, J Donnez, O Donnez, MM Dolmans - Fertility and Sterility, 2018 - Elsevier
Adenomyosis is a commonly diagnosed estrogen-dependent gynecological disorder that
causes pelvic pain, abnormal uterine bleeding, and infertility. Despite its prevalence and …

Adenomyosis: mechanisms and pathogenesis

J Zhai, S Vannuccini, F Petraglia… - Seminars in …, 2020 - thieme-connect.com
Adenomyosis is a common disorder of the uterus, and is associated with an enlarged uterus,
heavy menstrual bleeding (HMB), pelvic pain, and infertility. It is characterized by …

[HTML][HTML] Diagnosis of deep endometriosis: clinical examination, ultrasonography, magnetic resonance imaging, and other techniques

M Bazot, E Daraï - Fertility and sterility, 2017 - Elsevier
The aim of the present review was to evaluate the contribution of clinical examination and
imaging techniques, mainly transvaginal sonography and magnetic resonance imaging …