[HTML][HTML] Biological properties of SARS-CoV-2 variants: epidemiological impact and clinical consequences

R Hoteit, HM Yassine - Vaccines, 2022 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a virus that belongs to
the coronavirus family and is the cause of coronavirus disease 2019 (COVID-19). As of May …

Duration of infectious virus shedding by SARS-CoV-2 Omicron variant–infected vaccinees

K Takahashi, M Ishikane, M Ujiie… - Emerging infectious …, 2022 - pmc.ncbi.nlm.nih.gov
To determine virus shedding duration, we examined clinical samples collected from the
upper respiratory tracts of persons infected with severe acute respiratory syndrome …

[HTML][HTML] SARS-CoV-2 Omicron variant, lineage BA. 1, is associated with lower viral load in nasopharyngeal samples compared to Delta variant

C Sentis, G Billaud, A Bal, E Frobert, M Bouscambert… - Viruses, 2022 - mdpi.com
Objectives: High viral load in upper respiratory tract specimens observed for Delta cases
might contribute to its increased infectivity compared to the other variant. However, it is not …

Epidemiological and clinical characteristics of vaccinated COVID-19 patients: a meta-analysis and systematic review

W Tian, X Ren, M Han, Y Zhang… - International …, 2022 - journals.sagepub.com
Objective: With the global epidemic of coronavirus disease 2019 (COVID-19), vaccination
rates are increasing globally. This study evaluated the relevant clinical manifestations of …

Initial analysis of viral dynamics and circulating viral variants during the mRNA-1273 Phase 3 COVE trial

R Pajon, YD Paila, B Girard, G Dixon, K Kacena… - Nature medicine, 2022 - nature.com
The mRNA-1273 vaccine for coronavirus disease 2019 (COVID-19) demonstrated 93.2%
efficacy in reduction of symptomatic severe acute respiratory syndrome coronavirus 2 (SARS …

Agent-based modelling of reactive vaccination of workplaces and schools against COVID-19

B Faucher, R Assab, J Roux, D Levy-Bruhl… - Nature …, 2022 - nature.com
With vaccination against COVID-19 stalled in some countries, increasing vaccine
accessibility and distribution could help keep transmission under control. Here, we study the …

SARS-CoV-2 viral load in the nasopharynx at time of first infection among unvaccinated individuals: a secondary cross-protocol analysis of 4 randomized trials

LH Fisher, JJ Kee, A Liu, CM Espinosa… - JAMA Network …, 2024 - jamanetwork.com
Importance SARS-CoV-2 viral load (VL) in the nasopharynx is difficult to quantify and
standardize across settings, but it may inform transmission potential and disease severity …

Analyzing and modeling the spread of SARS-CoV-2 Omicron lineages BA. 1 and BA. 2, France, September 2021–February 2022

MT Sofonea, B Roquebert, V Foulongne… - Emerging Infectious …, 2022 - pmc.ncbi.nlm.nih.gov
We analyzed 324,734 SARS-CoV-2 variant screening tests from France enriched with
16,973 whole-genome sequences sampled during September 1, 2021–February 28, 2022 …

Characteristics of hospitalized patients with SARS-CoV-2 infection during successive waves of the COVID-19 pandemic in a reference hospital in Spain

S Iftimie, AF López-Azcona, MJ Lozano-Olmo… - Scientific Reports, 2022 - nature.com
Since the beginning of the COVID-19 pandemic and until September 2021, Spain suffered
five waves of infection, the latter being related to the expansion of the Delta variant and with …

The global succinylation of SARS-CoV-2–infected host cells reveals drug targets

Q Liu, H Wang, H Zhang, L Sui, L Li, W Xu, S Du… - Proceedings of the …, 2022 - pnas.org
SARS-CoV-2, the causative agent of the COVID-19 pandemic, undergoes continuous
evolution, highlighting an urgent need for development of novel antiviral therapies. Here we …