Multimorbidity (two or more coexisting conditions in an individual) is a growing global
challenge with substantial effects on individuals, carers and society. Multimorbidity occurs a …

Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Interleukin-18 (IL-18) is a potent pro-inflammatory cytokine involved in host defense against
infections and regulates the innate and acquired immune response. IL-18 is produced by …

Mammalian telomeres consist of (TTAGGG) n repeats. Transcription of the C-rich strand
generates a G-rich RNA, termed TERRA, containing G-quadruplex structures. Recent …

Transformed cells must acquire specific characteristics to be malignant. Weinberg and
Hanahan characterize these characteristics as cancer hallmarks. Though these features are …

Cellular senescence is a pivotal factor contributing to aging and the pathophysiology of age-
related diseases. Despite the presence of inflammation and abnormal immune system …

Background Elderly patients often exhibit postoperative cognitive dysfunction (POCD), a
postsurgical decline in memory and executive function. Oxidative stress and …

Colorectal cancer (CRC) represents a significant global health burden, with high incidence
and mortality rates worldwide. Recent progress in research highlights the distinct clinical …

Digestive system diseases arise primarily through the interplay of genetic and environmental
influences; there is an urgent need in elucidating the pathogenic mechanisms of these …

Inflammation is believed to play a role in the progression of numerous human diseases.
Research has shown that inflammation and telomeres are involved in a feedback regulatory …