Copper is an essential trace element in biological systems, maintaining the activity of
enzymes and the function of transcription factors. However, at high concentrations, copper …

Rapid developments in Regenerative Medicine and Tissue Engineering has witnessed an
increasing drive toward clinical translation of breakthrough technologies. However, the …

Copper (Cu) is an essential micronutrient required for the activity of redox‐active enzymes
involved in critical metabolic reactions, signaling pathways, and biological functions …

This consensus statement on chronic hepatitis (CH) in dogs is based on the expert opinion
of 7 specialists with extensive experience in diagnosing, treating, and conducting clinical …

The metal/metal alloy-based implants and prostheses are in use for over a century, and the
rejections, revisions, and metal particle-based toxicities were reported concurrently …

Copper is a required nutrient for life and particularly important to the brain and central
nervous system. Indeed, copper redox activity is essential to maintaining normal …

Essential metals such as copper (Cu) and zinc (Zn) are important cofactors in diverse
cellular processes, while metal imbalance may impact or be altered by disease state. Cu is …

Bivalve hemocytes are oyster immune cells composed of several cellular subtypes with
different functions. Hemocytes accumulate high concentrations of copper (Cu) and exert …

Wilson disease (WD) is an autosomal recessive disorder of copper metabolism manifesting
with hepatic, neurological and psychiatric symptoms. The limitations of the currently …

Studies with Wilson disease model mice that accumulate excessive copper, due to a
dysfunctional ATP7B “copper pump” resulting in decreased biliary excretion, showed that …