The genetic basis of major depression
Major depressive disorder (MDD) is a common, debilitating, phenotypically heterogeneous
disorder with heritability ranges from 30% to 50%. Compared to other psychiatric disorders …
disorder with heritability ranges from 30% to 50%. Compared to other psychiatric disorders …
Personalized medicine and the power of electronic health records
Personalized medicine has largely been enabled by the integration of genomic and other
data with electronic health records (EHRs) in the United States and elsewhere. Increased …
data with electronic health records (EHRs) in the United States and elsewhere. Increased …
[HTML][HTML] ABO genotype alters the gut microbiota by regulating GalNAc levels in pigs
H Yang, J Wu, X Huang, Y Zhou, Y Zhang, M Liu, Q Liu… - Nature, 2022 - nature.com
The composition of the intestinal microbiome varies considerably between individuals and is
correlated with health. Understanding the extent to which, and how, host genetics …
correlated with health. Understanding the extent to which, and how, host genetics …
Electronic health records and polygenic risk scores for predicting disease risk
Accurate prediction of disease risk based on the genetic make-up of an individual is
essential for effective prevention and personalized treatment. Nevertheless, to date …
essential for effective prevention and personalized treatment. Nevertheless, to date …
The genetic basis for adult onset glaucoma: recent advances and future directions
Glaucoma, a diverse group of eye disorders that results in the degeneration of retinal
ganglion cells, is the world's leading cause of irreversible blindness. Apart from age and …
ganglion cells, is the world's leading cause of irreversible blindness. Apart from age and …
Obesity and eating behavior from the perspective of twin and genetic research
K Silventoinen, H Konttinen - Neuroscience & biobehavioral reviews, 2020 - Elsevier
Obesity has dramatically increased during the last decades and is currently one of the most
serious global health problems. We present a hypothesis that obesity is a neuro-behavioral …
serious global health problems. We present a hypothesis that obesity is a neuro-behavioral …
Genome-wide association meta-analysis yields 20 loci associated with gallstone disease
Gallstones are responsible for one of the most common diseases in the Western world and
are commonly treated with cholecystectomy. We perform a meta-analysis of two genome …
are commonly treated with cholecystectomy. We perform a meta-analysis of two genome …
Medical records-based chronic kidney disease phenotype for clinical care and “big data” observational and genetic studies
Abstract Chronic Kidney Disease (CKD) represents a slowly progressive disorder that is
typically silent until late stages, but early intervention can significantly delay its progression …
typically silent until late stages, but early intervention can significantly delay its progression …
Estimating the heritability of SARS-CoV-2 susceptibility and COVID-19 severity
SARS-CoV-2 has infected over 340 million people, prompting therapeutic research. While
genetic studies can highlight potential drug targets, understanding the heritability of SARS …
genetic studies can highlight potential drug targets, understanding the heritability of SARS …
Major depressive disorder: existing hypotheses about pathophysiological mechanisms and new genetic findings
Major depressive disorder (MDD) is a common mental disorder generally characterized by
symptoms associated with mood, pleasure and effectiveness in daily life activities. MDD is …
symptoms associated with mood, pleasure and effectiveness in daily life activities. MDD is …